Cytotoxicity of 6-acetonyldihydrochelerythrin, arnottianamide and 6-(2-hydoxypropyl)-dihydrochelerythrine towards human cancer cell lines

M. Sreelekha; N. P. Anto; R. J. Anto; P. M. Shafi

Cytotoxicity of 6-acetonyldihydrochelerythrin, arnottianamide and 6-(2-hydoxypropyl)-dihydrochelerythrine towards human cancer cell lines

M. Sreelekha, N. P. Anto, R. J. Anto, P. M. Shafi

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The alkaloids, 6-acetonyldihydrochelerythrin 1 and arnottianamide 2 have been isolated for the first time from conical prickles on the stem bark of Zanthoxylum rhetsa (Roxb.) DC. These compounds have been investigated for their cytotoxicity against seven cancer cell lines of various origins. The compound 1 is proved to be more potent as an anticancer agent and is very specific to the colon cancer cell line, SW-480 and cervical cancer cell line, HeLa. Compound 2 is more active against breast cancer cell lines. The change in anticancer activity of 1 after conversion to 6-(2-hydoxypropyl)-dihydrochelerythrine 3 has also been evaluated and a decrease in activity is observed.

Original language	English
Pages (from-to)	647-651
Number of pages	5
Journal	Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry
Volume	53
Issue number	5
State	Published - 1 Jan 2014
Externally published	Yes

Keywords

6-(2-hydoxypropyl)-dihydro chelerythrin
6-acetonyldihydrochelerythrin
Anticancer
Arnottianamide
Zanthoxylum rhetsa

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Cytotoxicity of 6-acetonyldihydrochelerythrin, arnottianamide and 6-(2-hydoxypropyl)-dihydrochelerythrine towards human cancer cell lines",

abstract = "The alkaloids, 6-acetonyldihydrochelerythrin 1 and arnottianamide 2 have been isolated for the first time from conical prickles on the stem bark of Zanthoxylum rhetsa (Roxb.) DC. These compounds have been investigated for their cytotoxicity against seven cancer cell lines of various origins. The compound 1 is proved to be more potent as an anticancer agent and is very specific to the colon cancer cell line, SW-480 and cervical cancer cell line, HeLa. Compound 2 is more active against breast cancer cell lines. The change in anticancer activity of 1 after conversion to 6-(2-hydoxypropyl)-dihydrochelerythrine 3 has also been evaluated and a decrease in activity is observed.",

keywords = "6-(2-hydoxypropyl)-dihydro chelerythrin, 6-acetonyldihydrochelerythrin, Anticancer, Arnottianamide, Zanthoxylum rhetsa",

author = "M. Sreelekha and Anto, \{N. P.\} and Anto, \{R. J.\} and Shafi, \{P. M.\}",

year = "2014",

month = jan,

day = "1",

language = "English",

volume = "53",

pages = "647--651",

journal = "Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry",

issn = "0376-4699",

publisher = "Scientific Publishers of India",

number = "5",

}

Cytotoxicity of 6-acetonyldihydrochelerythrin, arnottianamide and 6-(2-hydoxypropyl)-dihydrochelerythrine towards human cancer cell lines. / Sreelekha, M.; Anto, N. P.; Anto, R. J. et al.
In: Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, Vol. 53, No. 5, 01.01.2014, p. 647-651.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cytotoxicity of 6-acetonyldihydrochelerythrin, arnottianamide and 6-(2-hydoxypropyl)-dihydrochelerythrine towards human cancer cell lines

AU - Sreelekha, M.

AU - Anto, N. P.

AU - Anto, R. J.

AU - Shafi, P. M.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The alkaloids, 6-acetonyldihydrochelerythrin 1 and arnottianamide 2 have been isolated for the first time from conical prickles on the stem bark of Zanthoxylum rhetsa (Roxb.) DC. These compounds have been investigated for their cytotoxicity against seven cancer cell lines of various origins. The compound 1 is proved to be more potent as an anticancer agent and is very specific to the colon cancer cell line, SW-480 and cervical cancer cell line, HeLa. Compound 2 is more active against breast cancer cell lines. The change in anticancer activity of 1 after conversion to 6-(2-hydoxypropyl)-dihydrochelerythrine 3 has also been evaluated and a decrease in activity is observed.

AB - The alkaloids, 6-acetonyldihydrochelerythrin 1 and arnottianamide 2 have been isolated for the first time from conical prickles on the stem bark of Zanthoxylum rhetsa (Roxb.) DC. These compounds have been investigated for their cytotoxicity against seven cancer cell lines of various origins. The compound 1 is proved to be more potent as an anticancer agent and is very specific to the colon cancer cell line, SW-480 and cervical cancer cell line, HeLa. Compound 2 is more active against breast cancer cell lines. The change in anticancer activity of 1 after conversion to 6-(2-hydoxypropyl)-dihydrochelerythrine 3 has also been evaluated and a decrease in activity is observed.

KW - 6-(2-hydoxypropyl)-dihydro chelerythrin

KW - 6-acetonyldihydrochelerythrin

KW - Anticancer

KW - Arnottianamide

KW - Zanthoxylum rhetsa

UR - http://www.scopus.com/inward/record.url?scp=84901780821&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84901780821

SN - 0376-4699

VL - 53

SP - 647

EP - 651

JO - Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry

JF - Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry

IS - 5

ER -

Cytotoxicity of 6-acetonyldihydrochelerythrin, arnottianamide and 6-(2-hydoxypropyl)-dihydrochelerythrine towards human cancer cell lines

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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