d-Glutamate production by stressed Escherichia coli gives a clue for the hypothetical induction mechanism of the ALS disease

Edna Ben Izhak Monselise, Maria Vyazmensky, Tali Scherf, Albert Batushansky, Itzhak Fishov

Research output: Contribution to journalArticlepeer-review

Abstract

In the search for the origin of Amyotrophic Lateral Sclerosis disease (ALS), we hypothesized earlier (Monselise, 2019) that d-amino acids produced by stressed microbiome may serve as inducers of the disease development. Many examples of d-amino acid accumulation under various stress conditions were demonstrated in prokaryotic and eukaryotic cells. In this work, wild-type Escherichia coli, members of the digestive system, were subjected to carbon and nitrogen starvation stress. Using NMR and LC–MS techniques, we found for the first time that d-glutamate accumulated in the stressed bacteria but not in control cells. These results together with the existing knowledge, allow us to suggest a new insight into the pathway of ALS development: d-glutamate, produced by the stressed microbiome, induces neurobiochemical miscommunication setting on C1q of the complement system. Proving this insight may have great importance in preventive medicine of such MND modern-age diseases as ALS, Alzheimer, and Parkinson.

Original languageEnglish
Article number18247
JournalScientific Reports
Volume14
Issue number1
DOIs
StatePublished - 1 Dec 2024

Keywords

  • Eukaryotic and prokaryotic communication
  • Evolutionary approach
  • Mitochondria
  • d-glutamate and d-glutamate racemase

ASJC Scopus subject areas

  • General

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