TY - JOUR
T1 - D-pinitol protects against carbon Tetrachloride–Induced hepatotoxicity in rats
AU - Rengarajan, Thamaraiselvan
AU - Rajendran, Peramaiyan
AU - Nandakumar, Natarajan
AU - Lokeshkumar, Boobathy
AU - Balasubramanian, Maruthaiveeran Periyasamy
N1 - Publisher Copyright:
© 2015 Begell House, Inc.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - The aim of the study was to evaluate the protective activity of D-Pinitol against carbon tetrachloride (CCl4)–induced hepatotoxicity in rats. The animals were divided into six groups, with each group consisting of six animals. Group I animals served as normal controls and received olive oil vehicle (1.0 ml/kg body weight intraperitoneally). Group II rats served as CCl4 controls, which received 30% CCl4 suspended in olive oil (3.0 ml/kg body weight intraperitoneally) twice a week for 4 weeks. Group III rats were treated with 30% CCl4 suspended in olive oil (3.0 ml/kg body weight intraperitoneally) twice a week for 4 weeks, followed by D-Pinitol (100mg/kg body weight) given for 28 days intragastrically. Group IV rats received D-Pinitol alone at a concentration of 100 mg/kg body weight for 28 days intragastrically. At the end of the experimental period, serum marker enzymes and lipid peroxidation (LPO) levels were significantly increased in group II animals. On the other hand, D-Pinitol treatment significantly decreased marker enzymes and LPO levels and increased the antioxidant level. CYP expression was also investigated. Therefore, the present study revealed that D-Pinitol acts as a protective agent by decreasing metabolic activation of xenobiotics through its antioxidant nature.
AB - The aim of the study was to evaluate the protective activity of D-Pinitol against carbon tetrachloride (CCl4)–induced hepatotoxicity in rats. The animals were divided into six groups, with each group consisting of six animals. Group I animals served as normal controls and received olive oil vehicle (1.0 ml/kg body weight intraperitoneally). Group II rats served as CCl4 controls, which received 30% CCl4 suspended in olive oil (3.0 ml/kg body weight intraperitoneally) twice a week for 4 weeks. Group III rats were treated with 30% CCl4 suspended in olive oil (3.0 ml/kg body weight intraperitoneally) twice a week for 4 weeks, followed by D-Pinitol (100mg/kg body weight) given for 28 days intragastrically. Group IV rats received D-Pinitol alone at a concentration of 100 mg/kg body weight for 28 days intragastrically. At the end of the experimental period, serum marker enzymes and lipid peroxidation (LPO) levels were significantly increased in group II animals. On the other hand, D-Pinitol treatment significantly decreased marker enzymes and LPO levels and increased the antioxidant level. CYP expression was also investigated. Therefore, the present study revealed that D-Pinitol acts as a protective agent by decreasing metabolic activation of xenobiotics through its antioxidant nature.
KW - Antioxidant
KW - CCL
KW - CYP2E1
KW - D-pinitol
KW - Lipid peroxidation
UR - http://www.scopus.com/inward/record.url?scp=84947717053&partnerID=8YFLogxK
U2 - 10.1615/JEnvironPatholToxicolOncol.2015013837
DO - 10.1615/JEnvironPatholToxicolOncol.2015013837
M3 - Article
C2 - 26756422
AN - SCOPUS:84947717053
SN - 0731-8898
VL - 34
SP - 287
EP - 298
JO - Journal of Environmental Pathology, Toxicology and Oncology
JF - Journal of Environmental Pathology, Toxicology and Oncology
IS - 4
ER -