Dangerous liaisons: how helminths manipulate the intestinal epithelium

Danielle Karo-Atar, Alex Gregorieff, Irah L. King

Research output: Contribution to journalReview articlepeer-review

Abstract

Intestinal helminths remain highly pervasive throughout the animal kingdom by modulating multiple aspects of the host immune response. The intestinal epithelium functions as a physical barrier as well as a sentinel innate immune tissue with the ability to sense and respond to infectious agents. Although helminths form intimate interactions with the epithelium, comprehensive knowledge about host–helminth interactions at this dynamic interface is lacking. In addition, little is known about the ability of helminths to directly shape the fate of this barrier tissue. Here, we review the diverse pathways by which helminths regulate the epithelium and highlight the emerging field of direct helminth regulation of intestinal stem cell (ISC) fate and function.

Original languageEnglish
Pages (from-to)414-422
Number of pages9
JournalTrends in Parasitology
Volume39
Issue number6
DOIs
StatePublished - 1 Jun 2023
Externally publishedYes

Keywords

  • epithelial regeneration
  • helminths
  • host defense
  • intestinal epithelium
  • intestinal organoids

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

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