Data-driven analyses revealed the comorbidity landscape of tuberous sclerosis complex

Kun Hsing Yu, Oren Miron, Nathan Palmer, Dario R. Lemos, Kathe Fox, S. C. Kou, Mustafa Sahin, Isaac S. Kohane

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

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Tuberous sclerosis complex (TSC) is a genetic disorder affecting multiple organ systems observed in approximately 1 in 10,000 live births.1,2 Patients with TSC have a higher risk of developing benign tumors in the brain, kidneys, heart, liver, lungs, and skin, and a variety of neuropsychiatric disorders.3 However, due to the rarity of TSC, its comorbidity landscape has not been fully investigated. To characterize the comorbidities of TSC systematically, we employed a nationwide health insurance claims dataset to analyze the comorbidity landscape of TSC and determined the phenotypical differences between patients with TSC and participants without TSC matched on age and sex.
Original languageEnglish
Pages (from-to)974-976
Number of pages3
JournalNeurology
Volume91
Issue number21
DOIs
StatePublished - 1 Jan 2018
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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