Data-driven analyses revealed the comorbidity landscape of tuberous sclerosis complex

Kun Hsing Yu; Oren Miron; Nathan Palmer; Dario R. Lemos; Kathe Fox; S. C. Kou; Mustafa Sahin; Isaac S. Kohane

doi:10.1212/WNL.0000000000006546

Data-driven analyses revealed the comorbidity landscape of tuberous sclerosis complex

Kun Hsing Yu, Oren Miron, Nathan Palmer, Dario R. Lemos, Kathe Fox, S. C. Kou, Mustafa Sahin, Isaac S. Kohane

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Tuberous sclerosis complex (TSC) is a genetic disorder affecting multiple organ systems observed in approximately 1 in 10,000 live births.1,2 Patients with TSC have a higher risk of developing benign tumors in the brain, kidneys, heart, liver, lungs, and skin, and a variety of neuropsychiatric disorders.3 However, due to the rarity of TSC, its comorbidity landscape has not been fully investigated. To characterize the comorbidities of TSC systematically, we employed a nationwide health insurance claims dataset to analyze the comorbidity landscape of TSC and determined the phenotypical differences between patients with TSC and participants without TSC matched on age and sex.

Original language	English
Pages (from-to)	974-976
Number of pages	3
Journal	Neurology
Volume	91
Issue number	21
DOIs	https://doi.org/10.1212/WNL.0000000000006546
State	Published - 1 Jan 2018
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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10.1212/WNL.0000000000006546

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title = "Data-driven analyses revealed the comorbidity landscape of tuberous sclerosis complex",

abstract = "This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.Tuberous sclerosis complex (TSC) is a genetic disorder affecting multiple organ systems observed in approximately 1 in 10,000 live births.1,2 Patients with TSC have a higher risk of developing benign tumors in the brain, kidneys, heart, liver, lungs, and skin, and a variety of neuropsychiatric disorders.3 However, due to the rarity of TSC, its comorbidity landscape has not been fully investigated. To characterize the comorbidities of TSC systematically, we employed a nationwide health insurance claims dataset to analyze the comorbidity landscape of TSC and determined the phenotypical differences between patients with TSC and participants without TSC matched on age and sex.",

author = "Yu, {Kun Hsing} and Oren Miron and Nathan Palmer and Lemos, {Dario R.} and Kathe Fox and Kou, {S. C.} and Mustafa Sahin and Kohane, {Isaac S.}",

note = "Funding Information: K. Yu, O. Miron, N. Palmer, and D.R. Lemos report no disclosures relevant to the manuscript. K. Fox is employed by Aetna. S. Kou reports no disclosures relevant to the manuscript. M. Sahin received research funding from Roche, Novartis, Pfizer, and LAM Therapeutics, and served on the Scientific Advisory Board of Sage Therapeutics and PTEN Research Foundation and on the Professional Advisory Board of the Tuberous Sclerosis Alliance. I. Kohane reports no disclosures relevant to the manuscript. Go to Neurology.org/N for full disclosures. Funding Information: Study funded by the Harvard Data Science Fellowship. The computational infrastructure was supported by the NVIDIA Grant Program.",

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doi = "10.1212/WNL.0000000000006546",

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T1 - Data-driven analyses revealed the comorbidity landscape of tuberous sclerosis complex

AU - Yu, Kun Hsing

AU - Miron, Oren

AU - Palmer, Nathan

AU - Lemos, Dario R.

AU - Fox, Kathe

AU - Kou, S. C.

AU - Sahin, Mustafa

AU - Kohane, Isaac S.

N1 - Funding Information: K. Yu, O. Miron, N. Palmer, and D.R. Lemos report no disclosures relevant to the manuscript. K. Fox is employed by Aetna. S. Kou reports no disclosures relevant to the manuscript. M. Sahin received research funding from Roche, Novartis, Pfizer, and LAM Therapeutics, and served on the Scientific Advisory Board of Sage Therapeutics and PTEN Research Foundation and on the Professional Advisory Board of the Tuberous Sclerosis Alliance. I. Kohane reports no disclosures relevant to the manuscript. Go to Neurology.org/N for full disclosures. Funding Information: Study funded by the Harvard Data Science Fellowship. The computational infrastructure was supported by the NVIDIA Grant Program.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.Tuberous sclerosis complex (TSC) is a genetic disorder affecting multiple organ systems observed in approximately 1 in 10,000 live births.1,2 Patients with TSC have a higher risk of developing benign tumors in the brain, kidneys, heart, liver, lungs, and skin, and a variety of neuropsychiatric disorders.3 However, due to the rarity of TSC, its comorbidity landscape has not been fully investigated. To characterize the comorbidities of TSC systematically, we employed a nationwide health insurance claims dataset to analyze the comorbidity landscape of TSC and determined the phenotypical differences between patients with TSC and participants without TSC matched on age and sex.

AB - This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.Tuberous sclerosis complex (TSC) is a genetic disorder affecting multiple organ systems observed in approximately 1 in 10,000 live births.1,2 Patients with TSC have a higher risk of developing benign tumors in the brain, kidneys, heart, liver, lungs, and skin, and a variety of neuropsychiatric disorders.3 However, due to the rarity of TSC, its comorbidity landscape has not been fully investigated. To characterize the comorbidities of TSC systematically, we employed a nationwide health insurance claims dataset to analyze the comorbidity landscape of TSC and determined the phenotypical differences between patients with TSC and participants without TSC matched on age and sex.

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Data-driven analyses revealed the comorbidity landscape of tuberous sclerosis complex

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