@article{f7c236942e454c33841a37a23b24d15f,
title = "Deciphering the transcriptional network of the dendritic cell lineage",
abstract = "Although much progress has been made in the understanding of the ontogeny and function of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and functional specialization of DCs in vivo remains poorly understood. We made a comprehensive comparative analysis of CD8 +, CD103 +, CD11b + and plasmacytoid DC subsets, as well as macrophage DC precursors and common DC precursors, across the entire immune system. Here we characterized candidate transcriptional activators involved in the commitment of myeloid progenitor cells to the DC lineage and predicted regulators of DC functional diversity in tissues. We identified a molecular signature that distinguished tissue DCs from macrophages. We also identified a transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens.",
author = "{The Immunological Genome Project Consortium} and Miller, {Jennifer C.} and Brown, {Brian D.} and Tal Shay and Gautier, {Emmanuel L.} and Vladimir Jojic and Ariella Cohain and Gaurav Pandey and Marylene Leboeuf and Elpek, {Kutlu G.} and Julie Helft and Daigo Hashimoto and Andrew Chow and Jeremy Price and Melanie Greter and Milena Bogunovic and Angelique Bellemare-Pelletier and Frenette, {Paul S.} and Randolph, {Gwendalyn J.} and Turley, {Shannon J.} and Miriam Merad and Claudia Jakubzick and Best, {Adam J.} and Jamie Knell and Ananda Goldrath and Daphne Koller and Nadia Cohen and Patrick Brennan and Michael Brenner and Aviv Regev and Anne Fletcher and Deepali Malhotra and Radu Jianu and David Laidlaw and Jim Collins and Kavitha Narayan and Katelyn Sylvia and Joonsoo Kang and Roi Gazit and Rossi, {Derrick J.} and Francis Kim and Rao, {Tata Nageswara} and Amy Wagers and Shinton, {Susan A.} and Hardy, {Richard R.} and Paul Monach and Bezman, {Natalie A.} and Sun, {Joseph C.} and Kim, {Charlie C.} and Lanier, {Lewis L.} and Tracy Heng",
note = "Funding Information: We thank colleagues of the ImmGen Project, especially the technical team, including M. Painter, J. Ericson and S. Davis, for contributions; C. Benoist for contributions to the design and writing of the manuscript; and eBioscience and Affymetrix for support of the ImmGen Project. Supported by the National Institute of Allergy and Infectious Diseases of the US National Institutes of Health (R24 AI072073 to the ImmGen Project (led by C. Benoist); AI080884 and HL086899 to M.M.; JDRF172010770 and DP2DK083052-01 to B.D.B.; DK074500 and AI045757 to S.J.T.; HL69438, DK056638, HL097819 and HL097700 to P.S.F.; and U54CA149145 to V.J.).",
year = "2012",
month = sep,
day = "1",
doi = "10.1038/ni.2370",
language = "English",
volume = "13",
pages = "888--899",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Research",
number = "9",
}