Deep transcranial magnetic stimulation add-on for the treatment of auditory hallucinations: A double-blind study

Oded Rosenberg, Roman Gersner, Limor D. Klein, Moshe Kotler, Abraham Zangen, Pinhas Dannon

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Background: About 25% of schizophrenia patients with auditory hallucinations are refractory to pharmacotherapy and electroconvulsive therapy. We conducted a deep transcranial magnetic stimulation (TMS) pilot study in order to evaluate the potential clinical benefit of repeated left temporoparietal cortex stimulation in these patients. The results were encouraging, but a sham-controlled study was needed to rule out a placebo effect.Methods: A total of 18 schizophrenic patients with refractory auditory hallucinations were recruited, from Beer Yaakov MHC and other hospitals outpatient populations. Patients received 10 daily treatment sessions with low-frequency (1 Hz for 10 min) deep TMS applied over the left temporoparietal cortex, using the H1 coil at the intensity of 110% of the motor threshold. Procedure was either real or sham according to patient randomization. Patients were evaluated via the Auditory Hallucinations Rating Scale, Scale for the Assessment of Positive Symptoms-Negative Symptoms, Clinical Global Impressions, and Quality of Life Questionnaire.Results: In all, 10 patients completed the treatment (10 TMS sessions). Auditory hallucination scores of both groups improved; however, there was no statistical difference in any of the scales between the active and the sham treated groups.Conclusions: Low-frequency deep TMS to the left temporoparietal cortex using the protocol mentioned above has no statistically significant effect on auditory hallucinations or the other clinical scales measured in schizophrenic patients.Trial Registration: identifier: NCT00564096.

Original languageEnglish
Article number13
JournalAnnals of General Psychiatry
StatePublished - 6 May 2012

ASJC Scopus subject areas

  • Psychiatry and Mental health


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