Defective natural killing activity but retention of lymphocyte-mediated antibody-dependent cellular cytotoxicity in patients with the X-linked lymphoproliferative syndrome

Shmuel Argov; Donald R. Johnson; Michaeleen Collins; Hillel S. Koren; Helen Lipscomb; David T. Purtilo

doi:10.1016/0008-8749(86)90001-8

Defective natural killing activity but retention of lymphocyte-mediated antibody-dependent cellular cytotoxicity in patients with the X-linked lymphoproliferative syndrome

Shmuel Argov, Donald R. Johnson, Michaeleen Collins, Hillel S. Koren, Helen Lipscomb, David T. Purtilo

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Abstract

Cellular mediated immune responses in vitro of six males with X-linked lymphoproliferative syndrome (XLP) were investigated. Impaired natural killing (NK) activity compared to seven controls (P < 0.001) and interferon-α activation (P < 0.011) were detected. However, normal numbers of lymphocytes expressing NK-associated antigens (Leu-7 and MO1) and large granular lymphocytes (LGL) were observed in all patients. Normal lymphocyte-mediated antibody-dependent cellular cytotoxicity (ADCC) (P < 0.531) was found. NK and ADCC activities have been regarded as being mediated by the same subsets of lymphocytes, however, results of this study do not support this hypothesis: lymphocytes with impaired NK but normal ADCC functions ( NK^- K⁺) were found in males with XLP.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	Cellular Immunology
Volume	100
Issue number	1
DOIs	https://doi.org/10.1016/0008-8749(86)90001-8
State	Published - 1 Jan 1986
Externally published	Yes

ASJC Scopus subject areas

Immunology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0008-8749(86)90001-8

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title = "Defective natural killing activity but retention of lymphocyte-mediated antibody-dependent cellular cytotoxicity in patients with the X-linked lymphoproliferative syndrome",

abstract = "Cellular mediated immune responses in vitro of six males with X-linked lymphoproliferative syndrome (XLP) were investigated. Impaired natural killing (NK) activity compared to seven controls (P < 0.001) and interferon-α activation (P < 0.011) were detected. However, normal numbers of lymphocytes expressing NK-associated antigens (Leu-7 and MO1) and large granular lymphocytes (LGL) were observed in all patients. Normal lymphocyte-mediated antibody-dependent cellular cytotoxicity (ADCC) (P < 0.531) was found. NK and ADCC activities have been regarded as being mediated by the same subsets of lymphocytes, however, results of this study do not support this hypothesis: lymphocytes with impaired NK but normal ADCC functions ( NK- K+) were found in males with XLP.",

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T1 - Defective natural killing activity but retention of lymphocyte-mediated antibody-dependent cellular cytotoxicity in patients with the X-linked lymphoproliferative syndrome

AU - Argov, Shmuel

AU - Johnson, Donald R.

AU - Collins, Michaeleen

AU - Koren, Hillel S.

AU - Lipscomb, Helen

AU - Purtilo, David T.

PY - 1986/1/1

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N2 - Cellular mediated immune responses in vitro of six males with X-linked lymphoproliferative syndrome (XLP) were investigated. Impaired natural killing (NK) activity compared to seven controls (P < 0.001) and interferon-α activation (P < 0.011) were detected. However, normal numbers of lymphocytes expressing NK-associated antigens (Leu-7 and MO1) and large granular lymphocytes (LGL) were observed in all patients. Normal lymphocyte-mediated antibody-dependent cellular cytotoxicity (ADCC) (P < 0.531) was found. NK and ADCC activities have been regarded as being mediated by the same subsets of lymphocytes, however, results of this study do not support this hypothesis: lymphocytes with impaired NK but normal ADCC functions ( NK- K+) were found in males with XLP.

AB - Cellular mediated immune responses in vitro of six males with X-linked lymphoproliferative syndrome (XLP) were investigated. Impaired natural killing (NK) activity compared to seven controls (P < 0.001) and interferon-α activation (P < 0.011) were detected. However, normal numbers of lymphocytes expressing NK-associated antigens (Leu-7 and MO1) and large granular lymphocytes (LGL) were observed in all patients. Normal lymphocyte-mediated antibody-dependent cellular cytotoxicity (ADCC) (P < 0.531) was found. NK and ADCC activities have been regarded as being mediated by the same subsets of lymphocytes, however, results of this study do not support this hypothesis: lymphocytes with impaired NK but normal ADCC functions ( NK- K+) were found in males with XLP.

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Defective natural killing activity but retention of lymphocyte-mediated antibody-dependent cellular cytotoxicity in patients with the X-linked lymphoproliferative syndrome

Abstract

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