Defective oocytes as a possible cause of infertility in a β-thalassaemia major patient

B. E. Reubinoff, A. Simon, S. Friedler, J. G. Schenker, A. Lewin

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Impaired reproduction is common among patients afflicted with β-thalassaemia major and is attributed mainly to the deposition of haemosiderin in the pituitary gland and ovaries. In-vitro fertilization (IVF)-embryo transfer cycles including ovum donation cycles are described for the first time in a patient with β-thalassaemia major. The patient's oocytes were not fertilized by the husband's sperm in repeated IVF attempts. However, when donated oocytes were used, in two consecutive cycles, most were fertilized by the husband, yielding pregnancies after each embryo transfer. It is suggested that in this case of β-thalassaemia major, impaired oocyte function contributed to infertility. However, a possible association between thalassaemia major and defective oocytes should be tested on a basis of additional IVF-embryo transfer cycles in these patients.

Original languageEnglish
Pages (from-to)1143-1145
Number of pages3
JournalHuman Reproduction
Issue number6
StatePublished - 1 Jan 1994
Externally publishedYes


  • Defective oocytes
  • IVF
  • Ovum donation
  • β-thalassaemia major

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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