Delayed febrile response in old rats is not associated with an inability of hypothalamus to produce prostaglandin E2

Vadim Fraifeld; Lada Abramovich; Jacob Kaplanski

doi:10.1016/0047-6374(94)01554-Y

Delayed febrile response in old rats is not associated with an inability of hypothalamus to produce prostaglandin E₂

Vadim Fraifeld, Lada Abramovich, Jacob Kaplanski

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

E. coli lipopolysaccharide (100 μg per rat, i.p.) induced a twofold increase in hypothalamic prostaglandin E₂ (PGE₂ production both in young adult (8 months) and old (28-30 months) male Wistar rats. It seems that the ability of the hypothalamus to produce PGE₂ in response to bacterial endotoxin is not affected with aging, and hence delayed febrile response observed in old rats is not related to hypothalamic PGE₂ production.

Original language	English
Pages (from-to)	137-140
Number of pages	4
Journal	Mechanisms of Ageing and Development
Volume	79
Issue number	2-3
DOIs	https://doi.org/10.1016/0047-6374(94)01554-Y
State	Published - 14 Apr 1995

Keywords

Aging
Body temperature
Hypothalamic prostaglandin E
Lipopolysaccharide (LPS)

ASJC Scopus subject areas

Aging
Developmental Biology

Access to Document

10.1016/0047-6374(94)01554-Y

Cite this

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abstract = "E. coli lipopolysaccharide (100 μg per rat, i.p.) induced a twofold increase in hypothalamic prostaglandin E2 (PGE2 production both in young adult (8 months) and old (28-30 months) male Wistar rats. It seems that the ability of the hypothalamus to produce PGE2 in response to bacterial endotoxin is not affected with aging, and hence delayed febrile response observed in old rats is not related to hypothalamic PGE2 production.",

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AU - Abramovich, Lada

AU - Kaplanski, Jacob

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N2 - E. coli lipopolysaccharide (100 μg per rat, i.p.) induced a twofold increase in hypothalamic prostaglandin E2 (PGE2 production both in young adult (8 months) and old (28-30 months) male Wistar rats. It seems that the ability of the hypothalamus to produce PGE2 in response to bacterial endotoxin is not affected with aging, and hence delayed febrile response observed in old rats is not related to hypothalamic PGE2 production.

AB - E. coli lipopolysaccharide (100 μg per rat, i.p.) induced a twofold increase in hypothalamic prostaglandin E2 (PGE2 production both in young adult (8 months) and old (28-30 months) male Wistar rats. It seems that the ability of the hypothalamus to produce PGE2 in response to bacterial endotoxin is not affected with aging, and hence delayed febrile response observed in old rats is not related to hypothalamic PGE2 production.

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KW - Body temperature

KW - Hypothalamic prostaglandin E

KW - Lipopolysaccharide (LPS)

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