Delayed febrile response in old rats is not associated with an inability of hypothalamus to produce prostaglandin E2

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Abstract

E. coli lipopolysaccharide (100 μg per rat, i.p.) induced a twofold increase in hypothalamic prostaglandin E2 (PGE2 production both in young adult (8 months) and old (28-30 months) male Wistar rats. It seems that the ability of the hypothalamus to produce PGE2 in response to bacterial endotoxin is not affected with aging, and hence delayed febrile response observed in old rats is not related to hypothalamic PGE2 production.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalMechanisms of Ageing and Development
Volume79
Issue number2-3
DOIs
StatePublished - 14 Apr 1995

Keywords

  • Aging
  • Body temperature
  • Hypothalamic prostaglandin E
  • Lipopolysaccharide (LPS)

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