Delayed recognition of human immunodeficiency virus infection in preadolescent children

D. Persaud, S. Chandwani, M. Rigaud, E. Leibovitz, A. Kaul, R. Lawrence, H. Pollack, D. DiJohn, K. Krasinski, W. Borkowsky

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Thirty-two (18%) of 181 children cared for at our institution who were infected with the human immunodeficiency virus type 1 (HIV-1) were first seen, and HIV was diagnosed, when they were 4 years of age and older. Initial complaints or diagnoses for these children included the following: hematologic disorders (5) (3 idiopathic thrombocytopenic purpura, 1 neutropenia, 1 anemia); recurrent bacterial infections (10); Pneumocystis carinii pneumonia (3); developmental delay (1); skin disorders (2) (1 genital wart, 1 chronic zoster); weight loss (3); malignancy (1); and nephropathy (1). Eight children were referred for evaluation because of maternal HIV-1 infection. The risk factors for HIV-1 infection included maternal/perinatal exposure (22), perinatal blood transfusion (6), blood transfusion during infancy (2), and sexual abuse (2). Ten (31%) of the 32 children have subsequently died. The longest survival from perinatal infection was 12 years. HIV-1 infection in children can result in a prolonged clinical latency and can masquerade as other pathologic conditions. The absence of clinical symptoms in older children at risk for HIV-1 infection should not deter HIV testing.

Original languageEnglish
Pages (from-to)688-691
Number of pages4
Issue number5 I
StatePublished - 1 Dec 1992
Externally publishedYes


  • acquired immunodeficiency syndrome
  • human immunodeficiency virus
  • preadolescents

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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