TY - JOUR
T1 - Delineating the role of phytocompounds against anti-bacterial drug Resistance-An update
AU - Gahtori, Rekha
AU - Abomughaid, Mosleh Mohammad
AU - Negi, Nidhi
AU - Krishnan, Saravanan
AU - Dhanasekaran, Sugapriya
AU - Pandit, Soumya
AU - Priya, Kanu
AU - Bishi, Dillip Kumar
AU - Prasad, Ram
AU - Gupta, Piyush Kumar
N1 - Publisher Copyright:
© 2021 Centro Regional de Invest. Cientif. y Tecn.. All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Antibacterial resistance developed by bacteria due to the unlimited use of antibiotics has posed a challenge for human civilization. This kind of problem is not limited to India only, but it is a global concern. Nowadays, many treatments and medicines for bacterial diseases have been developed. However, they possess some drawbacks. Therefore, the alternative medicine has been used to target the drug resistant mechanisms and such medicines have less side effects which is becoming necessary. Natural products have traditionally or historically been of importance for the development of antibacterial agents and are also known to overcome bacterial drug resistance by directly targeting the drug resistance mechanisms in bacteria. In recent years, researchers have also focused on new drug discovery from plant-based research. They have looked on various phytocompounds as antibacterial agents. In the current review, we report various classes of secondary metabolites such as phenolic compounds, flavonoids, alkaloids, saponins, terpenes, quinones, and some essential oils that have been used as an antibacterial agent. In addition, we also discuss several mechanisms behind bacterial multi-drug resistance that are used during bacterial pathogenesis.
AB - Antibacterial resistance developed by bacteria due to the unlimited use of antibiotics has posed a challenge for human civilization. This kind of problem is not limited to India only, but it is a global concern. Nowadays, many treatments and medicines for bacterial diseases have been developed. However, they possess some drawbacks. Therefore, the alternative medicine has been used to target the drug resistant mechanisms and such medicines have less side effects which is becoming necessary. Natural products have traditionally or historically been of importance for the development of antibacterial agents and are also known to overcome bacterial drug resistance by directly targeting the drug resistance mechanisms in bacteria. In recent years, researchers have also focused on new drug discovery from plant-based research. They have looked on various phytocompounds as antibacterial agents. In the current review, we report various classes of secondary metabolites such as phenolic compounds, flavonoids, alkaloids, saponins, terpenes, quinones, and some essential oils that have been used as an antibacterial agent. In addition, we also discuss several mechanisms behind bacterial multi-drug resistance that are used during bacterial pathogenesis.
KW - Antibacterial
KW - Drug-resistance
KW - Mechanisms
KW - Medicinal plants
KW - Natural products
KW - Phytocompounds
UR - http://www.scopus.com/inward/record.url?scp=85115169817&partnerID=8YFLogxK
U2 - 10.32604/BIOCELL.2021.016484
DO - 10.32604/BIOCELL.2021.016484
M3 - Review article
AN - SCOPUS:85115169817
VL - 45
SP - 1465
EP - 1477
JO - Biocell
JF - Biocell
SN - 0327-9545
IS - 6
ER -