Delineating the role of phytocompounds against anti-bacterial drug Resistance-An update

Rekha Gahtori, Mosleh Mohammad Abomughaid, Nidhi Negi, Saravanan Krishnan, Sugapriya Dhanasekaran, Soumya Pandit, Kanu Priya, Dillip Kumar Bishi, Ram Prasad, Piyush Kumar Gupta

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Antibacterial resistance developed by bacteria due to the unlimited use of antibiotics has posed a challenge for human civilization. This kind of problem is not limited to India only, but it is a global concern. Nowadays, many treatments and medicines for bacterial diseases have been developed. However, they possess some drawbacks. Therefore, the alternative medicine has been used to target the drug resistant mechanisms and such medicines have less side effects which is becoming necessary. Natural products have traditionally or historically been of importance for the development of antibacterial agents and are also known to overcome bacterial drug resistance by directly targeting the drug resistance mechanisms in bacteria. In recent years, researchers have also focused on new drug discovery from plant-based research. They have looked on various phytocompounds as antibacterial agents. In the current review, we report various classes of secondary metabolites such as phenolic compounds, flavonoids, alkaloids, saponins, terpenes, quinones, and some essential oils that have been used as an antibacterial agent. In addition, we also discuss several mechanisms behind bacterial multi-drug resistance that are used during bacterial pathogenesis.

Original languageEnglish
Pages (from-to)1465-1477
Number of pages13
JournalBiocell
Volume45
Issue number6
DOIs
StatePublished - 1 Jan 2021
Externally publishedYes

Keywords

  • Antibacterial
  • Drug-resistance
  • Mechanisms
  • Medicinal plants
  • Natural products
  • Phytocompounds

ASJC Scopus subject areas

  • Cell Biology

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