Demonstration of mucus simulant clearance in a Bench-Model using acoustic Field-Integrated Intrapulmonary Percussive ventilation

Ephraim Gutmark, Vijay Anand, Aaron Wheeler, Alexander Zahn, Yuval Cavari, Tal Eluk, Maor Hay, David Katoshevski, Iris Gutmark-Little

Research output: Contribution to journalArticlepeer-review

Abstract

Intrapulmonary Percussive Ventilation (IPV) is a high-frequency airway clearance technique used to help in mucus transport for mechanically ventilated and unventilated patients. Despite the many years of usage, this technique does not provide clear evidence of its intended efficacy. This is mainly attributable to the lack of in vitro observations that show “mucokinesis” towards the direction of the mouth. In the current manuscript, we demonstrate and subsequently propose a mechanism that details the movement of a mucus simulant in the proximal (towards the mouthpiece) direction. Towards this end, a novel method utilizing a high-frequency acoustic field in addition to the conventional air pulsations brought forth by traditional IPV is proposed. Under these conditions, at certain parameter settings, it is shown that the simulant is broken down into much smaller parts and subsequently pushed in the upstream direction gradually over a period of half-hour.

Original languageEnglish
Article number111305
JournalJournal of Biomechanics
Volume144
DOIs
StatePublished - 1 Nov 2022

Keywords

  • High frequency airway clearance
  • IPV
  • Mucokinesis
  • Pulsed flow
  • Sound field
  • Ventilation

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

Fingerprint

Dive into the research topics of 'Demonstration of mucus simulant clearance in a Bench-Model using acoustic Field-Integrated Intrapulmonary Percussive ventilation'. Together they form a unique fingerprint.

Cite this