Dendritic spines are susceptible to structural alterations induced by degeneration of their presynaptic afferents

Gadi Benshalom, Edward L. White

    Research output: Contribution to journalArticlepeer-review

    21 Scopus citations

    Abstract

    The shape of dendritic spines in mouse Sm1 cortex, which synapse with degenerating thalamocortical axon terminals, differs significantly from that of adjacent spines along the same spiny dendrites, which synapse with intact axon terminals. It is concluded that this morphological difference results from focal alterations in the heads of spines imposed by the degeneration of their presynaptic afferents.

    Original languageEnglish
    Pages (from-to)377-382
    Number of pages6
    JournalBrain Research
    Volume443
    Issue number1-2
    DOIs
    StatePublished - 8 Mar 1988

    Keywords

    • Axospinous synaptic junction
    • Degeneration
    • Dendritic spine
    • Somatosensory cortex
    • Spiny stellate neuron
    • Structural alteration
    • Thalamocortical

    ASJC Scopus subject areas

    • General Neuroscience
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

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