Dendritic voltage dependent conductances increase the excitatory synaptic response and its postsynaptic inhibition in a reconstructed α-motoneuron: A computer model

G. Gradwohl; Y. Grossman

doi:10.1016/S0925-2312(01)00521-5

Dendritic voltage dependent conductances increase the excitatory synaptic response and its postsynaptic inhibition in a reconstructed α-motoneuron: A computer model

G. Gradwohl
, Y. Grossman

Physiology and Cell Biology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Mammalian spinal monosynaptic Ia EPSP and its postsynaptic: reciprocal depolarizing inhibition was studied using NEURON simulator in a morphologically and physiologically characterised α-motoneuron. Low g_Na and g_K located at the dendrites greatly enhanced EPSP_A+N maximal amplitude and its reciprocal inhibition. A small area of active dendrite is sufficient for obtaining the maximal increase in excitatory response for each g_Na. EPSP peak is monotonically augmented by raising g_Na, whereas inhibition is enhanced until a specific g_Na and a further increase diminishes the inhibitory effect. Computer simulations performed at four additional α-motoneurons yielded similar results.

Original language	English
Pages (from-to)	223-229
Number of pages	7
Journal	Neurocomputing
Volume	38-40
DOIs	https://doi.org/10.1016/S0925-2312(01)00521-5
State	Published - 1 Jun 2001

Keywords

Computer simulation
Dendritic voltage dependent channels
α-motoneuron

ASJC Scopus subject areas

Computer Science Applications
Cognitive Neuroscience
Artificial Intelligence

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10.1016/S0925-2312(01)00521-5

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title = "Dendritic voltage dependent conductances increase the excitatory synaptic response and its postsynaptic inhibition in a reconstructed α-motoneuron: A computer model",

abstract = "Mammalian spinal monosynaptic Ia EPSP and its postsynaptic: reciprocal depolarizing inhibition was studied using NEURON simulator in a morphologically and physiologically characterised α-motoneuron. Low gNa and gK located at the dendrites greatly enhanced EPSPA+N maximal amplitude and its reciprocal inhibition. A small area of active dendrite is sufficient for obtaining the maximal increase in excitatory response for each gNa. EPSP peak is monotonically augmented by raising gNa, whereas inhibition is enhanced until a specific gNa and a further increase diminishes the inhibitory effect. Computer simulations performed at four additional α-motoneurons yielded similar results.",

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T1 - Dendritic voltage dependent conductances increase the excitatory synaptic response and its postsynaptic inhibition in a reconstructed α-motoneuron

T2 - A computer model

AU - Gradwohl, G.

AU - Grossman, Y.

PY - 2001/6/1

Y1 - 2001/6/1

N2 - Mammalian spinal monosynaptic Ia EPSP and its postsynaptic: reciprocal depolarizing inhibition was studied using NEURON simulator in a morphologically and physiologically characterised α-motoneuron. Low gNa and gK located at the dendrites greatly enhanced EPSPA+N maximal amplitude and its reciprocal inhibition. A small area of active dendrite is sufficient for obtaining the maximal increase in excitatory response for each gNa. EPSP peak is monotonically augmented by raising gNa, whereas inhibition is enhanced until a specific gNa and a further increase diminishes the inhibitory effect. Computer simulations performed at four additional α-motoneurons yielded similar results.

AB - Mammalian spinal monosynaptic Ia EPSP and its postsynaptic: reciprocal depolarizing inhibition was studied using NEURON simulator in a morphologically and physiologically characterised α-motoneuron. Low gNa and gK located at the dendrites greatly enhanced EPSPA+N maximal amplitude and its reciprocal inhibition. A small area of active dendrite is sufficient for obtaining the maximal increase in excitatory response for each gNa. EPSP peak is monotonically augmented by raising gNa, whereas inhibition is enhanced until a specific gNa and a further increase diminishes the inhibitory effect. Computer simulations performed at four additional α-motoneurons yielded similar results.

KW - Computer simulation

KW - Dendritic voltage dependent channels

KW - α-motoneuron

UR - https://www.scopus.com/pages/publications/0035383923

U2 - 10.1016/S0925-2312(01)00521-5

DO - 10.1016/S0925-2312(01)00521-5

M3 - Article

AN - SCOPUS:0035383923

SN - 0925-2312

VL - 38-40

SP - 223

EP - 229

JO - Neurocomputing

JF - Neurocomputing

ER -

Dendritic voltage dependent conductances increase the excitatory synaptic response and its postsynaptic inhibition in a reconstructed α-motoneuron: A computer model

Abstract

Keywords

ASJC Scopus subject areas

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