Densely Packed Hydrophobic Clustering: Encapsulated Valerates Form a High-Temperature-Stable {Mo132} Capsule System

Somenath Garai, Hartmut Bögge, Alice Merca, Olga A. Petina, Alina Grego, Pierre Gouzerh, Erhard T.K. Haupt, Ira A. Weinstock, Achim Müller

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Porous molecular nanocontainers of {Mo132}-type Keplerates offer unique opportunities to study a wide variety of relevant phenomena. An impressive example is provided by the highly reactive {Mo132-CO3} capsule, the reaction of which with valeric acid results in the very easy release of carbon dioxide and the uptake of 24 valerate ions/ligands that are integrated as a densely packed aggregate, thus indicating the unique possibility of hydrophobic clustering inside the cavity. Two-dimensional NMR techniques were used to demonstrate the presence of the 24 valerates and the stability of the capsule up to ca. 100 °C. Increasing the number of hydrophobic parts enhances the stability of the whole system. This situation also occurs in biological systems, such as globular proteins or protein pockets. United we stand: A water-soluble metal-oxide nanocapsule entraps 24 valerates to form a densely packed aggregate that is stabilized by hydrophobic interactions in a manner reminiscent of hydrophobic clustering in globular proteins.

Original languageEnglish
Pages (from-to)6634-6637
Number of pages4
JournalAngewandte Chemie - International Edition
Volume55
Issue number23
DOIs
StatePublished - 1 Jun 2016

Keywords

  • NMR spectroscopy
  • confinement effects
  • dense packing
  • hydrophobic interactions
  • porous capsules

ASJC Scopus subject areas

  • Catalysis
  • Chemistry (all)

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