Deoxynivalenol: An Overview on Occurrence, Chemistry, Biosynthesis, Health Effects and Its Detection, Management, and Control Strategies in Food and Feed

Madhu Kamle; Dipendra Kumar Mahato; Akansha Gupta; Shikha Pandhi; Bharti Sharma; Kajal Dhawan; Vasundhara; Sadhna Mishra; Manoj Kumar; Abhishek Dutt Tripathi; Prasad Rasane; Raman Selvakumar; Arvind Kumar; Shirani Gamlath; Pradeep Kumar

doi:10.3390/microbiolres13020023

Deoxynivalenol: An Overview on Occurrence, Chemistry, Biosynthesis, Health Effects and Its Detection, Management, and Control Strategies in Food and Feed

Madhu Kamle, Dipendra Kumar Mahato, Akansha Gupta, Shikha Pandhi, Bharti Sharma, Kajal Dhawan, Vasundhara, Sadhna Mishra, Manoj Kumar, Abhishek Dutt Tripathi, Prasad Rasane, Raman Selvakumar, Arvind Kumar, Shirani Gamlath, Pradeep Kumar

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Mycotoxins are fungi-produced secondary metabolites that can contaminate many foods eaten by humans and animals. Deoxynivalenol (DON), which is formed by Fusarium, is one of the most common occurring predominantly in cereal grains and thus poses a significant health risk. When DON is ingested, it can cause both acute and chronic toxicity. Acute signs include abdominal pain, anorexia, diarrhea, increased salivation, vomiting, and malaise. The most common effects of chronic DON exposure include changes in dietary efficacy, weight loss, and anorexia. This review provides a succinct overview of various sources, biosynthetic mechanisms, and genes governing DON production, along with its consequences on human and animal health. It also covers the effect of environmental factors on its production with potential detection, management, and control strategies.

Original language	English
Pages (from-to)	293-314
Number of pages	22
Journal	Microbiology Research
Volume	13
Issue number	2
DOIs	https://doi.org/10.3390/microbiolres13020023
State	Published - 1 Jun 2022
Externally published	Yes

Keywords

deoxynivalenol
food and feed contamination
human health
management strategies

ASJC Scopus subject areas

Microbiology
Molecular Biology
Microbiology (medical)

Access to Document

10.3390/microbiolres13020023

Cite this

Kamle, M., Mahato, D. K., Gupta, A., Pandhi, S., Sharma, B., Dhawan, K., Vasundhara, Mishra, S., Kumar, M., Tripathi, A. D., Rasane, P., Selvakumar, R., Kumar, A., Gamlath, S., & Kumar, P. (2022). Deoxynivalenol: An Overview on Occurrence, Chemistry, Biosynthesis, Health Effects and Its Detection, Management, and Control Strategies in Food and Feed. Microbiology Research, 13(2), 293-314. https://doi.org/10.3390/microbiolres13020023

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title = "Deoxynivalenol: An Overview on Occurrence, Chemistry, Biosynthesis, Health Effects and Its Detection, Management, and Control Strategies in Food and Feed",

abstract = "Mycotoxins are fungi-produced secondary metabolites that can contaminate many foods eaten by humans and animals. Deoxynivalenol (DON), which is formed by Fusarium, is one of the most common occurring predominantly in cereal grains and thus poses a significant health risk. When DON is ingested, it can cause both acute and chronic toxicity. Acute signs include abdominal pain, anorexia, diarrhea, increased salivation, vomiting, and malaise. The most common effects of chronic DON exposure include changes in dietary efficacy, weight loss, and anorexia. This review provides a succinct overview of various sources, biosynthetic mechanisms, and genes governing DON production, along with its consequences on human and animal health. It also covers the effect of environmental factors on its production with potential detection, management, and control strategies.",

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author = "Madhu Kamle and Mahato, {Dipendra Kumar} and Akansha Gupta and Shikha Pandhi and Bharti Sharma and Kajal Dhawan and Vasundhara and Sadhna Mishra and Manoj Kumar and Tripathi, {Abhishek Dutt} and Prasad Rasane and Raman Selvakumar and Arvind Kumar and Shirani Gamlath and Pradeep Kumar",

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Kamle, M, Mahato, DK, Gupta, A, Pandhi, S, Sharma, B, Dhawan, K, Vasundhara, Mishra, S, Kumar, M, Tripathi, AD, Rasane, P, Selvakumar, R, Kumar, A, Gamlath, S & Kumar, P 2022, 'Deoxynivalenol: An Overview on Occurrence, Chemistry, Biosynthesis, Health Effects and Its Detection, Management, and Control Strategies in Food and Feed', Microbiology Research, vol. 13, no. 2, pp. 293-314. https://doi.org/10.3390/microbiolres13020023

TY - JOUR

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T2 - An Overview on Occurrence, Chemistry, Biosynthesis, Health Effects and Its Detection, Management, and Control Strategies in Food and Feed

AU - Kamle, Madhu

AU - Mahato, Dipendra Kumar

AU - Gupta, Akansha

AU - Pandhi, Shikha

AU - Sharma, Bharti

AU - Dhawan, Kajal

AU - Vasundhara,

AU - Mishra, Sadhna

AU - Kumar, Manoj

AU - Tripathi, Abhishek Dutt

AU - Rasane, Prasad

AU - Selvakumar, Raman

AU - Kumar, Arvind

AU - Gamlath, Shirani

AU - Kumar, Pradeep

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Mycotoxins are fungi-produced secondary metabolites that can contaminate many foods eaten by humans and animals. Deoxynivalenol (DON), which is formed by Fusarium, is one of the most common occurring predominantly in cereal grains and thus poses a significant health risk. When DON is ingested, it can cause both acute and chronic toxicity. Acute signs include abdominal pain, anorexia, diarrhea, increased salivation, vomiting, and malaise. The most common effects of chronic DON exposure include changes in dietary efficacy, weight loss, and anorexia. This review provides a succinct overview of various sources, biosynthetic mechanisms, and genes governing DON production, along with its consequences on human and animal health. It also covers the effect of environmental factors on its production with potential detection, management, and control strategies.

AB - Mycotoxins are fungi-produced secondary metabolites that can contaminate many foods eaten by humans and animals. Deoxynivalenol (DON), which is formed by Fusarium, is one of the most common occurring predominantly in cereal grains and thus poses a significant health risk. When DON is ingested, it can cause both acute and chronic toxicity. Acute signs include abdominal pain, anorexia, diarrhea, increased salivation, vomiting, and malaise. The most common effects of chronic DON exposure include changes in dietary efficacy, weight loss, and anorexia. This review provides a succinct overview of various sources, biosynthetic mechanisms, and genes governing DON production, along with its consequences on human and animal health. It also covers the effect of environmental factors on its production with potential detection, management, and control strategies.

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Deoxynivalenol: An Overview on Occurrence, Chemistry, Biosynthesis, Health Effects and Its Detection, Management, and Control Strategies in Food and Feed

Abstract

Keywords

ASJC Scopus subject areas

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