Existing proofs that deduce BPL = L from circuit lower bounds convert randomized algorithms into deterministic algorithms with large constant overhead in space. We study space-bounded derandomization with minimal footprint, and ask what is the minimal possible space overhead for derandomization. We show that BPSPACE[S] ⊆ DSPACE[c·S] for c ≈ 2, assuming space-efficient cryptographic PRGs, and, either: (1) lower bounds against bounded-space algorithms with advice, or: (2) lower bounds against certain uniform compression algorithms. Under additional assumptions regarding the power of catalytic computation, in a new setting of parameters that was not studied before, we are even able to get c ≈ 1. Our results are constructive: Given a candidate hard function (and a candidate cryptographic PRG) we show how to transform the randomized algorithm into an efficient deterministic one. This follows from new PRGs and targeted PRGs for space-bounded algorithms, which we combine with novel space-efficient evaluation methods. A central ingredient in all our constructions is hardness amplification reductions in logspace-uniform TC0, that were not known before.