Design and synthesis of angularly annulated spirocyclics via enyne metathesis and the Diels-Alder reaction as key steps

Sambasivarao Kotha, Rashid Ali, Arti Tiwari

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

We have developed a simple and an efficient route to a range of angularly fused spirocycles by the application of enyne metathesis and the Diels-Alder reaction as key steps. The enyne metathesis protocol has been further extended to the dibenzylation of indane-1,3-dione by using cross-enyne metathesis in the presence of hexa-1,5-diene with the aid of Grubbs' 1st generation catalyst followed by an aromatization sequence with DDQ.

Original languageEnglish
Article numberss-2014-n0101-op
Pages (from-to)2471-2480
Number of pages10
JournalSynthesis (Germany)
Volume46
Issue number18
DOIs
StatePublished - 1 Jan 2014
Externally publishedYes

Keywords

  • Diels-Alder reaction
  • active methylene compounds
  • cross-metathesis
  • enyne metathesis
  • spirocyclic compounds

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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