Abstract
We have developed a simple and an efficient route to a range of angularly fused spirocycles by the application of enyne metathesis and the Diels-Alder reaction as key steps. The enyne metathesis protocol has been further extended to the dibenzylation of indane-1,3-dione by using cross-enyne metathesis in the presence of hexa-1,5-diene with the aid of Grubbs' 1st generation catalyst followed by an aromatization sequence with DDQ.
Original language | English |
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Article number | ss-2014-n0101-op |
Pages (from-to) | 2471-2480 |
Number of pages | 10 |
Journal | Synthesis (Germany) |
Volume | 46 |
Issue number | 18 |
DOIs | |
State | Published - 1 Jan 2014 |
Externally published | Yes |
Keywords
- Diels-Alder reaction
- active methylene compounds
- cross-metathesis
- enyne metathesis
- spirocyclic compounds
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry