Design and synthesis of broad-based mono- and bi- cyclic inhibitors of FIV and HIV proteases

Keyphrases

• Bicyclol 100%
• Macrocycles 100%
• HIV-1 Protease 100%
• Monocyclic 100%
• Drug Resistance 33%
• Amino 33%
• Protease 33%
• 4-phenylbutyric Acid (4-PBA) 33%
• Resistant mutants 33%
• Transition State 33%
• Unnatural Amino Acids 33%
• Multidrug-resistant 33%
• Ring Width 33%
• Tissue Culture 33%
• Tripeptide 33%
• Inhibitory Activity 33%
• Highly Effective 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Macrocyclic Compound 100%
• HIV 100%
• Human Immunodeficiency Virus Proteinase 100%
• 3 Amino 2 Hydroxy 4 Phenylbutyric Acid 33%
• Tripeptide 33%
• Amino Acid 33%
• Drug Resistance 33%

Chemistry

• Macrocycle 100%
• 4-Phenylbutyric Acid 33%
• Phe-Val 33%
• Transition State 33%
• Amino Acid 33%
• Tripeptide 33%
• Val-Ala 33%