Design, synthesis and biological evaluation of 1,3-diaminopropanes: A new class of polyamine analogs as leishmanicidal agents

Versha Vinay Kumar; Sudhir K. Singh; S. Sharma; A. P. Bhaduri; Suman Gupta; Alima Zaidi; Suman Tiwari; J. C. Katiyar

doi:10.1016/S0960-894X(97)00087-5

Design, synthesis and biological evaluation of 1,3-diaminopropanes: A new class of polyamine analogs as leishmanicidal agents

Versha Vinay Kumar, Sudhir K. Singh, S. Sharma, A. P. Bhaduri, Suman Gupta, Alima Zaidi, Suman Tiwari, J. C. Katiyar

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Analogs of 1,3-diaminopropane as inhibitors for the growth of Leishmania donovani have been synthesized and evaluated for their antileishmanial activity. Of the many active compounds, 1-(3-N,N-bis methoxycarbonyl guanidino)propyl-4- methylpiperidine piperazine (4e,f) exhibited significant in vivo inhibitory efficacy against L. donovani by oral and intraperitoneal route of administration.

Original language	English
Pages (from-to)	675-680
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(97)00087-5
State	Published - 18 Mar 1997
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(97)00087-5

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title = "Design, synthesis and biological evaluation of 1,3-diaminopropanes: A new class of polyamine analogs as leishmanicidal agents",

abstract = "Analogs of 1,3-diaminopropane as inhibitors for the growth of Leishmania donovani have been synthesized and evaluated for their antileishmanial activity. Of the many active compounds, 1-(3-N,N-bis methoxycarbonyl guanidino)propyl-4- methylpiperidine piperazine (4e,f) exhibited significant in vivo inhibitory efficacy against L. donovani by oral and intraperitoneal route of administration.",

author = "Kumar, {Versha Vinay} and Singh, {Sudhir K.} and S. Sharma and Bhaduri, {A. P.} and Suman Gupta and Alima Zaidi and Suman Tiwari and Katiyar, {J. C.}",

note = "Funding Information: Acknowledgements: The authors are grateful to Dr. V.R Kamboj, FNA, Director, CDRI, Lucknow (India) for providing necessary facilities. We are also thankful to RSIC Division, CDRI for providing spectroscopical data. VVK thanks to CSIR, New Delhi for the award of Research Associateship.",

year = "1997",

month = mar,

day = "18",

doi = "10.1016/S0960-894X(97)00087-5",

language = "English",

volume = "7",

pages = "675--680",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Design, synthesis and biological evaluation of 1,3-diaminopropanes

T2 - A new class of polyamine analogs as leishmanicidal agents

AU - Kumar, Versha Vinay

AU - Singh, Sudhir K.

AU - Sharma, S.

AU - Bhaduri, A. P.

AU - Gupta, Suman

AU - Zaidi, Alima

AU - Tiwari, Suman

AU - Katiyar, J. C.

N1 - Funding Information: Acknowledgements: The authors are grateful to Dr. V.R Kamboj, FNA, Director, CDRI, Lucknow (India) for providing necessary facilities. We are also thankful to RSIC Division, CDRI for providing spectroscopical data. VVK thanks to CSIR, New Delhi for the award of Research Associateship.

PY - 1997/3/18

Y1 - 1997/3/18

N2 - Analogs of 1,3-diaminopropane as inhibitors for the growth of Leishmania donovani have been synthesized and evaluated for their antileishmanial activity. Of the many active compounds, 1-(3-N,N-bis methoxycarbonyl guanidino)propyl-4- methylpiperidine piperazine (4e,f) exhibited significant in vivo inhibitory efficacy against L. donovani by oral and intraperitoneal route of administration.

AB - Analogs of 1,3-diaminopropane as inhibitors for the growth of Leishmania donovani have been synthesized and evaluated for their antileishmanial activity. Of the many active compounds, 1-(3-N,N-bis methoxycarbonyl guanidino)propyl-4- methylpiperidine piperazine (4e,f) exhibited significant in vivo inhibitory efficacy against L. donovani by oral and intraperitoneal route of administration.

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U2 - 10.1016/S0960-894X(97)00087-5

DO - 10.1016/S0960-894X(97)00087-5

M3 - Article

AN - SCOPUS:0031576894

SN - 0960-894X

VL - 7

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EP - 680

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Design, synthesis and biological evaluation of 1,3-diaminopropanes: A new class of polyamine analogs as leishmanicidal agents

Abstract

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