Designing RNA switches for synthetic biology using inverse-RNA-folding

Sumit Mukherjee, Danny Barash

Research output: Contribution to journalShort surveypeer-review


RNA switches respond to specific ligands to control gene expression. They are widely used in synthetic biology applications and hold potential for future RNA-based therapeutic breakthroughs. However, the crux is their precise design. Here, we will discuss how inverse-RNA-folding could be utilized for the accurate design of RNA switches.

Original languageEnglish
Pages (from-to)517-521
Number of pages5
JournalTrends in Biotechnology
Issue number5
StatePublished - 1 May 2024


  • RNA switch
  • RNA-based therapeutics
  • inverse-RNA-folding
  • riboswitch
  • ribozyme
  • synthetic biology

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology


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