Detection of Chlamydia trachomatis antigens in urine as an alternative to swabs and cultures

Max Chemesky, Santina Castriciano, John Sellors, Iain Stewart, Ian Cunningham, Stephan Landis, William Seidelman, Lorna Grant, Corinne Devlin, James Mahony

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


By using commercially available spectrophotometric and immunofluorescent immunoassays, Chlamydia trachomatis antigens were detected in first-void urine (FVU) sediments from 224 men attending a sexually transmitted disease clinic at a frequency of 81.6%-86.8% compared with 86.8% (33/38) positive by urethral swab culture (P<.05). Endocervical cultures from 228 women attending a gynecologyclinic yielded 92.3% (12/13) positive compared with 61.5%76.9% for urine samples in three antigen-detection assays. Culturing urine from either gender yielded low positivity rates (23.7% for men, 15.4% for women). Defining truly infected patients as positive by culture or byany two of the three antigen tests, all assays were 100% specific. Immunodiagnostic testing of male FVU sediment appears to bea reliable, rapid, nontraumatic method for diagnosing chlamydia infection.

Original languageEnglish
Pages (from-to)124-126
Number of pages3
JournalJournal of Infectious Diseases
Issue number1
StatePublished - 1 Jan 1990
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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