TY - JOUR
T1 - Detection of S100B in maternal blood before and after fetal death
AU - Beharier, Ofer
AU - Shusterman, Eden
AU - Eshcoli, Tamar
AU - Szaingurten-Solodkin, Irit
AU - Aricha-Tamir, Barak
AU - Weintraub, Adi Y.
AU - Sheiner, Eyal
AU - Holcberg, Gershon
AU - Hershkovitz, Reli
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Background: S100B is a brain damage biomarker. When measured immediately after birth, it reflects neonatal brain damage following asphyxia. In this study, we used feticide as a novel model of fetal brain damage. We examined whether such damage is reflected by a rise in S100B in maternal blood before delivery. Methods: Eight pregnant women were recruited between January and July 2012. Maternal blood samples were drawn before and after feticide at predetermined time points (0, 15, 30, 60, 120, and 240min). S100B, lactate dehydrogenase, creatine kinase, and creatinine concentrations were measured by standard human ELISA and chemical analyzer. Results: No significant difference was noted between S100B levels before and after feticide, neither in non-specific cell death markers (lactate dehydrogenase and creatine kinase), which remained within normal range. S100B ranged between 0.015-0.04μg/L through all the predetermined time points. Conclusion: No statistically significant differences were demonstrated in S100B levels before and after feticide.
AB - Background: S100B is a brain damage biomarker. When measured immediately after birth, it reflects neonatal brain damage following asphyxia. In this study, we used feticide as a novel model of fetal brain damage. We examined whether such damage is reflected by a rise in S100B in maternal blood before delivery. Methods: Eight pregnant women were recruited between January and July 2012. Maternal blood samples were drawn before and after feticide at predetermined time points (0, 15, 30, 60, 120, and 240min). S100B, lactate dehydrogenase, creatine kinase, and creatinine concentrations were measured by standard human ELISA and chemical analyzer. Results: No significant difference was noted between S100B levels before and after feticide, neither in non-specific cell death markers (lactate dehydrogenase and creatine kinase), which remained within normal range. S100B ranged between 0.015-0.04μg/L through all the predetermined time points. Conclusion: No statistically significant differences were demonstrated in S100B levels before and after feticide.
UR - https://www.scopus.com/pages/publications/84891547997
U2 - 10.1002/pd.4266
DO - 10.1002/pd.4266
M3 - Article
C2 - 24178516
AN - SCOPUS:84891547997
SN - 0197-3851
VL - 34
SP - 94
EP - 97
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
IS - 1
ER -
