DeubiKuitylation: A novel DUB enzymatic activity for the DNA repair protein, Ku70

Moran Rathaus, Batya Lerrer, Haim Y. Cohen

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

The Ku70 protein was shown to be involved in multiple cellular pathways including DNA repair, telomere maintenance, V(D)J recombination and Bax mediated apoptosis. Yet, despite this wide spectrum of pathways, until recently the enzymatic activity of Ku70 was elusive. Recent findings demonstrate that Ku70 is associated with the proapoptotic protein Bax and possesses a deubiquitin enzyme (DUB) activity on it. These data suggest a dual role for Ku70 in apoptotic regulation; on one hand the association with Ku70 sequestered Bax away from the mitochondria and plays an antiapoptotic function. On the other hand, this association mediates and promotes Bax deubiquitylation which will block its labeling for proteasomal degradation and in this manner Ku70 will have a proapoptotic role. The exciting finding of Ku70's DUB activity opens numerous avenues for future research. Here we suggest candidate substrate proteins and indicate how the DUB activity of Ku70 on these, might affect the known Ku70's related pathways.

Original languageEnglish
Pages (from-to)1843-1852
Number of pages10
JournalCell Cycle
Volume8
Issue number12
DOIs
StatePublished - 15 Jun 2009
Externally publishedYes

Keywords

  • Apoptosis
  • Bax
  • Deubiquitylation (DUB)
  • Ku70

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'DeubiKuitylation: A novel DUB enzymatic activity for the DNA repair protein, Ku70'. Together they form a unique fingerprint.

Cite this