Developing a theoretical evolutionary framework to solve the mystery of parturition initiation

Antonis Rokas, Sam Mesiano, Ortal Tamam, Abigail Labella, Ge Zhang, Louis Muglia

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Eutherian mammals have characteristic lengths of gestation that are key for reproductive success, but relatively little is known about the processes that determine the timing of parturition, the process of birth, and how they are coordinated with fetal developmental programs. This issue remains one of biology’s great unsolved mysteries and has significant clinical relevance because preterm birth is the leading cause of infant and under 5 year old child mortality worldwide. Here, we consider the evolutionary influences and potential signaling mechanisms that maintain or end pregnancy in eutherian mammals and use this knowledge to formulate general theoretical evolutionary models. These models can be tested through evolutionary species comparisons, studies of experimental manipulation of gestation period and birth timing, and human clinical studies. Understanding how gestation time and parturition are determined will shed light on this fundamental biological process and improve human health through the development of therapies to prevent preterm birth.

Original languageEnglish
Article numbere58343
Pages (from-to)1-22
Number of pages22
JournaleLife
Volume9
DOIs
StatePublished - 1 Dec 2020

ASJC Scopus subject areas

  • Neuroscience (all)
  • Biochemistry, Genetics and Molecular Biology (all)
  • Immunology and Microbiology (all)

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