Development of Analog-Specific Immunoassays for Pharmacokinetic Studies of Insulin Lispro and Insulin Aspart

Lindy Kahanovitz; Patrick M Sluss; Norman W Lautsch; Robert S Marks; Steven J Russell

doi:10.2337/db17-890-1488

Development of Analog-Specific Immunoassays for Pharmacokinetic Studies of Insulin Lispro and Insulin Aspart

Lindy Kahanovitz, Patrick M Sluss, Norman W Lautsch, Robert S Marks, Steven J Russell

Department of Biotechnology Engineering

Research output: Contribution to journal › Meeting Abstract

Abstract

Specific measurement of rapid-acting insulin analogs has been complicated by lack of specificity due to structural similarity of the analogs. We
have developed novel immunoassays that specifically measure insulin
aspart (Novolog) and insulin lispro (Humalog) using new monoclonal antibodies and the Meso Scale Discovery platform.

Original language	English
Article number	1030‑P
Pages (from-to)	A271-A271
Number of pages	1
Journal	Diabetes
Volume	66
Issue number	supplement 1
DOIs	https://doi.org/10.2337/db17-890-1488
State	Published - Jun 2017

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title = "Development of Analog-Specific Immunoassays for Pharmacokinetic Studies of Insulin Lispro and Insulin Aspart",

abstract = "Specific measurement of rapid-acting insulin analogs has been complicated by lack of specificity due to structural similarity of the analogs. Wehave developed novel immunoassays that specifically measure insulinaspart (Novolog) and insulin lispro (Humalog) using new monoclonal antibodies and the Meso Scale Discovery platform.",

author = "Lindy Kahanovitz and Sluss, {Patrick M} and Lautsch, {Norman W} and Marks, {Robert S} and Russell, {Steven J}",

year = "2017",

month = jun,

doi = "10.2337/db17-890-1488",

language = "English",

volume = "66",

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T1 - Development of Analog-Specific Immunoassays for Pharmacokinetic Studies of Insulin Lispro and Insulin Aspart

AU - Kahanovitz, Lindy

AU - Sluss, Patrick M

AU - Lautsch, Norman W

AU - Marks, Robert S

AU - Russell, Steven J

PY - 2017/6

Y1 - 2017/6

N2 - Specific measurement of rapid-acting insulin analogs has been complicated by lack of specificity due to structural similarity of the analogs. Wehave developed novel immunoassays that specifically measure insulinaspart (Novolog) and insulin lispro (Humalog) using new monoclonal antibodies and the Meso Scale Discovery platform.

AB - Specific measurement of rapid-acting insulin analogs has been complicated by lack of specificity due to structural similarity of the analogs. Wehave developed novel immunoassays that specifically measure insulinaspart (Novolog) and insulin lispro (Humalog) using new monoclonal antibodies and the Meso Scale Discovery platform.

U2 - 10.2337/db17-890-1488

DO - 10.2337/db17-890-1488

M3 - Meeting Abstract

SN - 0012-1797

VL - 66

SP - A271-A271

JO - Diabetes

JF - Diabetes

IS - supplement 1

M1 - 1030‑P

ER -

Development of Analog-Specific Immunoassays for Pharmacokinetic Studies of Insulin Lispro and Insulin Aspart

Abstract

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