Development of spinal cord on a microfludic chip

Sareen Dhruv; S Kerns Jordan; Wen Norman; Lucchesi Carol; Hinojosa Chris; Fraser Jacob; Hamilton Geraldine; Vatine Gad; Sances Samuel; Svendsen Clive; Levner Daniel

Development of spinal cord on a microfludic chip

Sareen Dhruv (Inventor), S Kerns Jordan (Inventor), Wen Norman (Inventor), Lucchesi Carol (Inventor), Hinojosa Chris (Inventor), Fraser Jacob (Inventor), Hamilton Geraldine (Inventor), Vatine Gad (Inventor), Sances Samuel (Inventor), Svendsen Clive (Inventor), Levner Daniel (Inventor)

Department of Physiology and Cell Biology

Research output: Patent

Abstract

The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.

Original language	English
Patent number	GB2568446
IPC	C12N 15/ 85 A I
Priority date	29/08/17
State	Published - 15 May 2019

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title = "Development of spinal cord on a microfludic chip",

abstract = "The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.",

author = "Sareen Dhruv and Jordan, {S Kerns} and Wen Norman and Lucchesi Carol and Hinojosa Chris and Fraser Jacob and Hamilton Geraldine and Vatine Gad and Sances Samuel and Svendsen Clive and Levner Daniel",

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T1 - Development of spinal cord on a microfludic chip

AU - Dhruv, Sareen

AU - Jordan, S Kerns

AU - Norman, Wen

AU - Carol, Lucchesi

AU - Chris, Hinojosa

AU - Jacob, Fraser

AU - Geraldine, Hamilton

AU - Gad, Vatine

AU - Samuel, Sances

AU - Clive, Svendsen

AU - Daniel, Levner

PY - 2019/5/15

Y1 - 2019/5/15

N2 - The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.

AB - The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.

M3 - Patent

M1 - GB2568446

ER -

Development of spinal cord on a microfludic chip

Abstract

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