Development of spinal cord on a microfluidic chip

Jordan Kerns; Norman Wen; Carol Lucchesi; Christopher Hinojosa; Jacob Fraser; Geraldine Hamilton; Gad Vatine; Sam Sances; Clive Svendsen; Daniel Levner

Development of spinal cord on a microfluidic chip

Jordan Kerns (Inventor)
, Norman Wen (Inventor)
, Carol Lucchesi (Inventor)
, Christopher Hinojosa (Inventor)
, Jacob Fraser (Inventor)
, Geraldine Hamilton (Inventor)
, Gad Vatine (Inventor)
, Sam Sances (Inventor)
, Clive Svendsen (Inventor)
, Daniel Levner (Inventor)

Department of Physiology and Cell Biology

Research output: Patent

Abstract

The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.

Original language	English
Patent number	US2018057788
State	Published - 1 Mar 2018

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title = "Development of spinal cord on a microfluidic chip",

abstract = "The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.",

author = "Jordan Kerns and Norman Wen and Carol Lucchesi and Christopher Hinojosa and Jacob Fraser and Geraldine Hamilton and Gad Vatine and Sam Sances and Clive Svendsen and Daniel Levner",

note = "US Patent App. 15/352,289; US2018057788",

year = "2018",

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type = "Patent",

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TY - PAT

T1 - Development of spinal cord on a microfluidic chip

AU - Kerns, Jordan

AU - Wen, Norman

AU - Lucchesi, Carol

AU - Hinojosa, Christopher

AU - Fraser, Jacob

AU - Hamilton, Geraldine

AU - Vatine, Gad

AU - Sances, Sam

AU - Svendsen, Clive

AU - Levner, Daniel

N1 - US Patent App. 15/352,289

PY - 2018/3/1

Y1 - 2018/3/1

N2 - The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.

AB - The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.

M3 - Patent

M1 - US2018057788

ER -

Development of spinal cord on a microfluidic chip

Abstract

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