Developmental aspects of T-suppressor cells induced by hapten-carrier conjugates.

M. Ritterband; A. Globerson

doi:10.1007/978-1-4684-9066-4_100

Developmental aspects of T-suppressor cells induced by hapten-carrier conjugates.

M. Ritterband, A. Globerson

Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The capacity of newborn liver and of aging mouse spleen to give rise to suppressor cells interfering specifically with an anti-hapten antibody response was investigated. The experimental system to induce suppressor cells was used on sequential treatment with a hapten (DNP or NIP) coupled to two different carrier molecules (i.e., DNP-RSA and DNP-BGG, respectively). Suppressor cells developing under such conditions are Thy 1.2+, nylon wool effluent, PNA+, I-J+ cells. Newborn liver cells were found to be capable of differentiating into such suppressors. Aging mouse spleen cells did not manifest such specific suppression, yet they did interfere with the antibody response in a nonspecific manner.

Original language	English
Pages (from-to)	725-731
Number of pages	7
Journal	Advances in Experimental Medicine and Biology
Volume	149
DOIs	https://doi.org/10.1007/978-1-4684-9066-4_100
State	Published - 1 Jan 1982

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General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4684-9066-4_100

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title = "Developmental aspects of T-suppressor cells induced by hapten-carrier conjugates.",

abstract = "The capacity of newborn liver and of aging mouse spleen to give rise to suppressor cells interfering specifically with an anti-hapten antibody response was investigated. The experimental system to induce suppressor cells was used on sequential treatment with a hapten (DNP or NIP) coupled to two different carrier molecules (i.e., DNP-RSA and DNP-BGG, respectively). Suppressor cells developing under such conditions are Thy 1.2+, nylon wool effluent, PNA+, I-J+ cells. Newborn liver cells were found to be capable of differentiating into such suppressors. Aging mouse spleen cells did not manifest such specific suppression, yet they did interfere with the antibody response in a nonspecific manner.",

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AU - Globerson, A.

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N2 - The capacity of newborn liver and of aging mouse spleen to give rise to suppressor cells interfering specifically with an anti-hapten antibody response was investigated. The experimental system to induce suppressor cells was used on sequential treatment with a hapten (DNP or NIP) coupled to two different carrier molecules (i.e., DNP-RSA and DNP-BGG, respectively). Suppressor cells developing under such conditions are Thy 1.2+, nylon wool effluent, PNA+, I-J+ cells. Newborn liver cells were found to be capable of differentiating into such suppressors. Aging mouse spleen cells did not manifest such specific suppression, yet they did interfere with the antibody response in a nonspecific manner.

AB - The capacity of newborn liver and of aging mouse spleen to give rise to suppressor cells interfering specifically with an anti-hapten antibody response was investigated. The experimental system to induce suppressor cells was used on sequential treatment with a hapten (DNP or NIP) coupled to two different carrier molecules (i.e., DNP-RSA and DNP-BGG, respectively). Suppressor cells developing under such conditions are Thy 1.2+, nylon wool effluent, PNA+, I-J+ cells. Newborn liver cells were found to be capable of differentiating into such suppressors. Aging mouse spleen cells did not manifest such specific suppression, yet they did interfere with the antibody response in a nonspecific manner.

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ER -

Developmental aspects of T-suppressor cells induced by hapten-carrier conjugates.

Abstract

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