Dexamethasone inhalations in RSV bronchiolitis: A double-blind, placebo-controlled study

Lea Bentur, David Shoseyov, David Feigenbaum, Yilena Gorichovsky, Haim Bibi

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Objective: To evaluate the effect of inhaled dexamethasone on hospitalization for respiratory syncytial virus (RSV) bronchiolitis. Study design: A double-blind, placebo-controlled study compared nebulization of dexamethasone versus nebulization of 0.9% saline. Both groups were treated with epinephrine nebulizations. Follow-up continued for 3 mo. Patients and methods: Sixty-one infants with bronchiolitis aged 3 to 12 mo were included. They were randomly allocated to nebulizations with 0.25 mg dexamethasone every 6 h (group 1) or an equivalent amount of normal saline (group 2). Results: No statistically significant differences with respect to clinical score, oxygen saturation, or IV fluid requirement between the groups were noted. Using Kaplan-Meyer's method, the cumulative proportion of in-hospital stay was significantly lower in group 1 compared with group 2, mainly in days 5 and 6 post-hospitalization (p < 0.038). A subgroup of prematurely born children in group 1 had a shorter hospitalization period (6.5 ± 1.7 d) compared with group 2 children (9.1 ± 1.9) (p < 0.018). Follow-up revealed similar wheeze and hospitalization rates in the two groups. Conclusion: Inhaled dexamethasone may reduce the length of hospitalization among infants with acute viral bronchiolitis, especially among those born prematurely.

Original languageEnglish
Pages (from-to)866-871
Number of pages6
JournalActa Paediatrica, International Journal of Paediatrics
Volume94
Issue number7
DOIs
StatePublished - 1 Jul 2005

Keywords

  • Inhaled dexamethasone
  • RSV Bronchiolitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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