Diabetes insipidus caused by isolated intracranial metatstases in patient with breast cancer

Dmitri Bobilev, Ilan Shelef, Konstantin Lavrenkov, Margarita Tokar, Sofia Man, Amalia Baumgarten, Samuel Ariad

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We present a case of late recurrence of breast cancer manifested with diabetes insipidus caused by isolated intracranial metastases. A 57-year-old postmenopausal woman was diagnosed with breast cancer and underwent radical mastectomy, without any adjuvant therapy. Seventeen years later, she presented with polyuria, polydipsia, weight loss, weakness, diffuse bone pain, hoarseness and mild dyspnoea. Cranial CT revealed several dural masses in the frontal, parietal and occipital lobes and along the falx cerebri. The diagnosis of central diabetes insipidus without impairment of anterior pituitary function was based on the clinical symptoms, laboratory tests and imaging findings. The patient was successfully treated with desmopressin acetate and letrozole, and remained alive and ambulating 22 months after initial presentation with diabetes insipidus.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalJournal of Neuro-Oncology
Volume73
Issue number1
DOIs
StatePublished - 1 May 2005

Keywords

  • Breast cancer
  • Diabetes insipidus
  • Dural metastases
  • Letrozole

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