Diagnostic Approach to Prenatally Diagnosed Limb Abnormalities

Arie Koifman, Ori Nevo, Ants Toi, David Chitayat

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Limb formation occurs at 4-12 weeks gestation and involves many genes and gene families. The prevalence of limb abnormalities is approximately 6/10,000 live births, with higher incidence in the upper limbs compared to the lower limbs (3.4/10,000 and 1.1/10,000 respectively). Limb abnormalities are morphologically and etiologically heterogenous group of abnormalities and most are amenable for prenatal diagnosis. The investigation and counselling of woman/couple with prenatally diagnosed fetal limb abnormality requires a multidisciplinary team including obstetrician, radiologist, clinical geneticist, neonatologist/pediatrician and a pediatric orthopedic surgeon. Other specialties may be needed if other abnormalities are detected.

Original languageEnglish
Pages (from-to)595-608
Number of pages14
JournalUltrasound Clinics
Volume3
Issue number4
DOIs
StatePublished - 1 Oct 2008
Externally publishedYes

Keywords

  • Detection and diagnosis of limb abnormalities using prenatal ultrasound

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