Diagnostic Yield of Critical Sample and Elective Fast-Test in Children After a Hypoglycemic Event: Experience From a Single Center in Israel

Lior Carmon, Ran Hazan, Eli Hershkovitz, Odeya David, David Shaki, Dganit Walker, Neta Loewenthal, Majd Nasar, Guy Hazan, Alon Haim

    Research output: Contribution to journalArticlepeer-review

    Abstract

    OBJECTIVE: To determine the diagnostic yield of the critical sample and fast-tests as dynamic function tests for the work-up of hypoglycemia in children. METHODS: A retrospective record review of children (0-18 years) with a diagnosis of hypoglycemia (glucose ≤ 50 mg/dL) was performed. A comparison of results of critical sample (obtained during an episode of hypoglycemia) and fast-test (performed to induce hypoglycemia in fasting state) was done. RESULTS: In 317 patients with hypoglycemia, data of 89 critical samples and 52 fast-tests were taken. Only 7 (7.8%) patients who underwent critical sample testing received an endocrine or metabolic diagnosis. No confirmatory diagnoses were made using the fast-tests. Idiopathic ketotic hypoglycemia was detected in 33/89 (37.1%) of critical samples and 21/52 (40.4%) of fast-tests. The completeness of workup including the hormonal and metabolic profile was <80% in both tests. CONCLUSION: The confirmatory yield of critical sample was better than fast-test. The processing of metabolic analytes was incomplete in a few, suggesting the need to rationalize the dynamic function testing.

    Original languageEnglish
    Pages (from-to)348-351
    Number of pages4
    JournalIndian Pediatrics
    Volume61
    Issue number4
    StatePublished - 15 Apr 2024

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health

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