Dibromochloropropane (DBCP): An 8-year reevaluation of testicular function and reproductive performance

G. Potashnik, I. Yanai-Inbar

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

The current study summarizes an 8-year reassessment of testicular function and reproductive performance in 15 workers with dibromochloropropane (DBCP)-induced azoospermia and oligozoospermia. Recovery of spermatogenesis was observed in four oligozoospermic and three azoospermic men whose plasma follicle-stimulating hormone (FSH) concentration was normal during the whole period. A marked increase in FSH and luteinizing hormone concentrations above the upper limit of normal was found in the azoospermic workers who did not recover. No significant changes in FSH concentrations were detected in both recovered and nonrecovered oligozoospermic men. Testosterone levels of all patients were normal at all times. Paternal exposure to DBCP was not associated with increased risk of fetal malformations or spontaneous abortion.

Original languageEnglish
Pages (from-to)317-323
Number of pages7
JournalFertility and Sterility
Volume47
Issue number2
DOIs
StatePublished - 1 Jan 1987
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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