Diet and lupus

A. Leiba, H. Amital, M. E. Gershwin, Y. Shoenfeld

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


The effect of dietary modifications has been extensively studied in lupus animal models. Calorie, protein, and especially fat restriction, caused a significant reduction in immune-complex deposition in the kidney, reduced proteinuria and prolongation of the mice's life span. The addition of polyunsaturated fatty acids (PUFAs), such as fish oil or linseed oil, was also related to decreased mice morbidity and mortality in animal models of lupus and of antiphospholipid syndrome. PUFAs such as eicosapetaenoic acid (EPA) and docosahexaenoic acid (DHA) competitively inhibit arachidonic acid with a resultant decrease in inflammatory eicosanoids and cytokines. Human studies support the effect of a PUFAs-enriched diet, both scrologically and clinically. Large scale clinical studies are needed to confirm the primary results.

Original languageEnglish
Pages (from-to)246-248
Number of pages3
Issue number3
StatePublished - 1 Jan 2001
Externally publishedYes


  • Autoimmune diseases
  • Fish oil
  • Linseed oil
  • Lupus erythematosus
  • Polyunsaturated fatty acids (PUFAs)

ASJC Scopus subject areas

  • Rheumatology


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