Differences in cell surface antigens of tumor metastases and those of the local tumor

Mina Fogel, Eliezer Gorelik, Shraga Segal, Michael Feldman

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

Tests were made to determine whether cell surface tumor antigens of metastases differed from the tumor antigens of the cell population of the local tumor growth. C57BL/6 mouse spleen lymphocytes sensitized against monolayers of the local growth of the 3LL Lewis lung carcinoma (L-3LL) in the presence of syngeneic serum generated lymphocytes that were cytotoxic to L-3LL but significantly less cytotoxic to target cells derived from lung metastases (M-3LL). Lymphocytes sensitized against M-3LL were significantly more cytotoxic against M-3LL than against L-3LL cells. Anti-M-3LL cytotoxic lymphocytes but not anti-L-3LL, admixed with either L-3LL cells or M-3LL tumor cells, when injected into syngeneic recipients reduced lung metastasis significantly. Results indicated that cells with high metastatic capacity and distinct antigenic properties exist within the tumor cell population and that immunoselection might be involved in the production of lung metastases.

Original languageEnglish
Pages (from-to)585-588
Number of pages4
JournalJournal of the National Cancer Institute
Volume62
Issue number3
DOIs
StatePublished - 1 Jan 1979
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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