Different noses for different people

Idan Menashe; Orna Man; Doron Lancet; Yoav Gilad

doi:10.1038/ng1160

Different noses for different people

Idan Menashe, Orna Man, Doron Lancet, Yoav Gilad

Research output: Contribution to journal › Article › peer-review

202 Scopus citations

Abstract

Of more than 1,000 human olfactory receptor genes, more than half seem to be pseudogenes. We investigated whether the most recent of these disruptions might still segregate with the intact form by genotyping 51 candidate genes in 189 ethnically diverse humans. The results show an unprecedented prevalence of segregating pseudogenes, identifying one of the most pronounced cases of functional population diversity in the human genome.

Original language	English GB
Pages (from-to)	143-144
Number of pages	2
Journal	Nature Genetics
Volume	34
Issue number	2
DOIs	https://doi.org/10.1038/ng1160
State	Published - 1 Jun 2003
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1038/ng1160

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abstract = "Of more than 1,000 human olfactory receptor genes, more than half seem to be pseudogenes. We investigated whether the most recent of these disruptions might still segregate with the intact form by genotyping 51 candidate genes in 189 ethnically diverse humans. The results show an unprecedented prevalence of segregating pseudogenes, identifying one of the most pronounced cases of functional population diversity in the human genome.",

author = "Idan Menashe and Orna Man and Doron Lancet and Yoav Gilad",

note = "Funding Information: We thank M. Przeworski for helpful discussions. D.L. holds the Ralph and Lois Silver Chair in Human Genomics. This work was supported by the Crown Human Genome Center at the Weizmann Institute of Science and by an Israel Ministry of Science grant to the National Laboratory for Genome Infrastructure.",

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AU - Gilad, Yoav

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N2 - Of more than 1,000 human olfactory receptor genes, more than half seem to be pseudogenes. We investigated whether the most recent of these disruptions might still segregate with the intact form by genotyping 51 candidate genes in 189 ethnically diverse humans. The results show an unprecedented prevalence of segregating pseudogenes, identifying one of the most pronounced cases of functional population diversity in the human genome.

AB - Of more than 1,000 human olfactory receptor genes, more than half seem to be pseudogenes. We investigated whether the most recent of these disruptions might still segregate with the intact form by genotyping 51 candidate genes in 189 ethnically diverse humans. The results show an unprecedented prevalence of segregating pseudogenes, identifying one of the most pronounced cases of functional population diversity in the human genome.

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Different noses for different people

Abstract

ASJC Scopus subject areas

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