Differential effect of initiating moderate red wine consumption on 24-h blood pressure by alcohol dehydrogenase genotypes: Randomized trial in type 2 diabetes

Yftach Gepner, Yaakov Henkin, Dan Schwarzfuchs, Rachel Golan, Ronen Durst, Ilan Shelef, Ilana Harman-Boehm, Shosana Spitzen, Shula Witkow, Lena Novack, Michael Friger, Osnat Tangi-Rosental, Dana Sefarty, Nitzan Bril, Michal Rein, Noa Cohen, Yoash Chassidim, Benny Sarusi, Talia Wolak, Meir J. StampferAssaf Rudich, Iris Shai

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

AIMS: Observational studies report inconsistent associations between moderate alcohol intake and blood pressure (BP). In a sub-study of a larger randomized controlled trial, we assessed the effect of initiating moderate red wine consumption on 24-h BP recordings and the effect of a common genetic variant of alcohol dehydrogenases (ADH) among patients with type 2 diabetes. METHODS: Fifty-four type 2 diabetes, alcohol abstainers were randomized to consume 150 ml/dinner dry red wine or mineral water. Both groups were guided to adhere to a Mediterranean diet, without caloric restriction. We measured 24-h ambulatory BP monitoring (ABPM) at baseline and after 6 months. RESULTS: Participants (age = 57 years; 85% men; mean 24-h BP = 129/77 mm Hg) had 92% 6-month retention. After 6 months of intervention, the average 24-h BP did not differ between the wine and water groups. A transient decrease in BP was observed in the red wine group at midnight (3-4 hours after wine intake: systolic BP: red wine = -10.6 mm Hg vs. mineral water = +2.3 mm Hg; P = 0.031) and the following morning at 7-9 am (red wine: -6.2 mm Hg vs. mineral water: +5.6 mm Hg; P = 0.014). In a second post hoc sub-analysis among the red wine consumers, individuals who were homozygous for the gene encoding ADH1B∗2 variant (Arg48His; rs1229984, TT, fast ethanol metabolizers), exhibited a reduction in mean 24-h systolic BP (-8.0 mm Hg vs. +3.7mm Hg; P = 0.002) and pulse pressure (-3.8 mm Hg vs. +1.2 mm Hg; P = 0.032) compared to heterozygotes and those homozygous for the ADH1B∗1 variant (CC, slow metabolizers). CONCLUSIONS: Initiating moderate red wine consumption at dinner among type 2 diabetes patients does not have a discernable effect on mean 24-h BP. Yet, a modest temporal BP reduction could be documented, and a more pronounced BP-lowering effect is suggested among fast ethanol metabolizers.

Original languageEnglish
Pages (from-to)476-483
Number of pages8
JournalAmerican Journal of Hypertension
Volume29
Issue number4
DOIs
StatePublished - 1 Apr 2016

Keywords

  • Ambulatory measurement
  • Blood pressure
  • Hypertension
  • Moderate alcohol
  • Pulse pressure
  • Randomized controlled trial
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine

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