Differential inhibition of cellular RNA by photosensitized trioxalen

Benny Shames, Sarit Kalma, Yair M. Heimer, Jacov Tal

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Treatment of mouse cell cultures with 5 × 10-6;M trioxalen (4,5′,8-trimethylpsoralen, or TMP) followed by long wavelength ("near") UV-irradiation (NUV) resulted 1n immediate cessation of most of the cellular transcriptional activity. The effective inhibitory TMP concentrations for ribosomal RNA were lower than those affecting poly RNA containing RNA. Low molecular RNA species were only partially inhibited. Side effects, commonly caused by other drugs, were not detected. These properties, and the simplicity of their use, make psoralens attractive Inhibitors of RNA biosynthesis.

Original languageEnglish
Pages (from-to)6453-6464
Number of pages12
JournalNucleic Acids Research
Issue number18
StatePublished - 24 Sep 1983

ASJC Scopus subject areas

  • Genetics


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