TY - JOUR
T1 - Differential processing of objects under various viewing conditions in the human lateral occipital complex
AU - Grill-Spector, Kalanit
AU - Kushnir, Tammar
AU - Edelman, Shimon
AU - Avidan, Galia
AU - Itzchak, Yacov
AU - Malach, Rafael
N1 - Funding Information:
This study was funded by ISF grant 131/97. We thank Y. Moses for providing the face database and E. Sali and A. Zeira for providing the car database. We thank E. Seidemann for assitance in performing the eye movement measurements, E. Okon for technical help and advice, and T. Hendler for helpful comments on the manuscript.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - The invariant properties of human cortical neurons cannot be studied directly by fMRI due to its limited spatial resolution. Here, we circumvented this limitation by using fMR adaptation, namely, reduction of the fMR signal due to repeated presentation of identical images. Object-selective regions (lateral occipital complex [LOC]) showed a monotonic signal decrease as repetition frequency increased. The invariant properties of fMR adaptation were studied by presenting the same object in different viewing conditions. LOC exhibited stronger fMR adaptation to changes in size and position (more invariance) compared to illumination and viewpoint. The effect revealed two putative subdivisions within LOC: caudal-dorsal (LO), which exhibited substantial recovery from adaptation under all transformations, and posterior fusiform (PF/LOa), which displayed stronger adaptation. This study demonstrates the utility of fMR adaptation for revealing functional characteristics of neurons in fMRI studies.
AB - The invariant properties of human cortical neurons cannot be studied directly by fMRI due to its limited spatial resolution. Here, we circumvented this limitation by using fMR adaptation, namely, reduction of the fMR signal due to repeated presentation of identical images. Object-selective regions (lateral occipital complex [LOC]) showed a monotonic signal decrease as repetition frequency increased. The invariant properties of fMR adaptation were studied by presenting the same object in different viewing conditions. LOC exhibited stronger fMR adaptation to changes in size and position (more invariance) compared to illumination and viewpoint. The effect revealed two putative subdivisions within LOC: caudal-dorsal (LO), which exhibited substantial recovery from adaptation under all transformations, and posterior fusiform (PF/LOa), which displayed stronger adaptation. This study demonstrates the utility of fMR adaptation for revealing functional characteristics of neurons in fMRI studies.
UR - http://www.scopus.com/inward/record.url?scp=0033200154&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(00)80832-6
DO - 10.1016/S0896-6273(00)80832-6
M3 - Article
AN - SCOPUS:0033200154
SN - 0896-6273
VL - 24
SP - 187
EP - 203
JO - Neuron
JF - Neuron
IS - 1
ER -