Differential regulation of prostaglandin synthesis in neonatal rat microglia and astrocytes by somatostatin

Julia Grinshpun; Liat Tveria; Sigal Fleisher-Berkovich

doi:10.1016/j.ejphar.2008.02.025

Differential regulation of prostaglandin synthesis in neonatal rat microglia and astrocytes by somatostatin

Julia Grinshpun, Liat Tveria, Sigal Fleisher-Berkovich

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The aim of the present study was to investigate the role of somatostatin in the regulation of brain inflammation. We used lipopolysaccharide-induced prostaglandin E₂ production in neonatal rat microglia and in astrocytes as a model of brain inflammation. Our data show an unexpected differential effect of somatostatin on lipopolysaccharide-induced prostaglandin E₂ synthesis in rat microglia vs. in astrocytes. Somatostatin markedly inhibited the lipopolysaccharide-induced prostaglandin E₂ synthesis in microglia whereas, on the contrary, in astrocytes the lipopolysaccharide-induced prostaglandin E₂ production was actually enhanced by somatostatin. These novel observations imply that somatostatin may regulate brain inflammation in a dual manner.

Original language	English
Pages (from-to)	312-317
Number of pages	6
Journal	European Journal of Pharmacology
Volume	584
Issue number	2-3
DOIs	https://doi.org/10.1016/j.ejphar.2008.02.025
State	Published - 28 Apr 2008

Keywords

Astrocytes
Lipopolysaccharide
Microglia
Prostaglandin E
Somatostatin

ASJC Scopus subject areas

Pharmacology

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10.1016/j.ejphar.2008.02.025

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title = "Differential regulation of prostaglandin synthesis in neonatal rat microglia and astrocytes by somatostatin",

abstract = "The aim of the present study was to investigate the role of somatostatin in the regulation of brain inflammation. We used lipopolysaccharide-induced prostaglandin E2 production in neonatal rat microglia and in astrocytes as a model of brain inflammation. Our data show an unexpected differential effect of somatostatin on lipopolysaccharide-induced prostaglandin E2 synthesis in rat microglia vs. in astrocytes. Somatostatin markedly inhibited the lipopolysaccharide-induced prostaglandin E2 synthesis in microglia whereas, on the contrary, in astrocytes the lipopolysaccharide-induced prostaglandin E2 production was actually enhanced by somatostatin. These novel observations imply that somatostatin may regulate brain inflammation in a dual manner.",

keywords = "Astrocytes, Lipopolysaccharide, Microglia, Prostaglandin E, Somatostatin",

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T1 - Differential regulation of prostaglandin synthesis in neonatal rat microglia and astrocytes by somatostatin

AU - Grinshpun, Julia

AU - Tveria, Liat

AU - Fleisher-Berkovich, Sigal

PY - 2008/4/28

Y1 - 2008/4/28

N2 - The aim of the present study was to investigate the role of somatostatin in the regulation of brain inflammation. We used lipopolysaccharide-induced prostaglandin E2 production in neonatal rat microglia and in astrocytes as a model of brain inflammation. Our data show an unexpected differential effect of somatostatin on lipopolysaccharide-induced prostaglandin E2 synthesis in rat microglia vs. in astrocytes. Somatostatin markedly inhibited the lipopolysaccharide-induced prostaglandin E2 synthesis in microglia whereas, on the contrary, in astrocytes the lipopolysaccharide-induced prostaglandin E2 production was actually enhanced by somatostatin. These novel observations imply that somatostatin may regulate brain inflammation in a dual manner.

AB - The aim of the present study was to investigate the role of somatostatin in the regulation of brain inflammation. We used lipopolysaccharide-induced prostaglandin E2 production in neonatal rat microglia and in astrocytes as a model of brain inflammation. Our data show an unexpected differential effect of somatostatin on lipopolysaccharide-induced prostaglandin E2 synthesis in rat microglia vs. in astrocytes. Somatostatin markedly inhibited the lipopolysaccharide-induced prostaglandin E2 synthesis in microglia whereas, on the contrary, in astrocytes the lipopolysaccharide-induced prostaglandin E2 production was actually enhanced by somatostatin. These novel observations imply that somatostatin may regulate brain inflammation in a dual manner.

KW - Astrocytes

KW - Lipopolysaccharide

KW - Microglia

KW - Prostaglandin E

KW - Somatostatin

UR - https://www.scopus.com/pages/publications/41349103186

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DO - 10.1016/j.ejphar.2008.02.025

M3 - Article

C2 - 18325491

AN - SCOPUS:41349103186

SN - 0014-2999

VL - 584

SP - 312

EP - 317

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

Differential regulation of prostaglandin synthesis in neonatal rat microglia and astrocytes by somatostatin

Abstract

Keywords

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