TY - CHAP
T1 - Differential sex-associated differences in immune responses to and osteoneogenesis of ectopically transplanted fetal bone allografts
T2 - Importance of H2 and non-H2 encoded alloantigens
AU - Segal, Shraga
AU - Altaratz, Chana
AU - Engelberg, Yitzhak S.
AU - Tartakovsky, Boris
AU - Nebel, Laslo
N1 - Publisher Copyright:
© 1990 by CRC Press, Inc.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Fetal bone allografts were transplanted in male and female recipients differing in major histocompatibility (MHC) H2 and non-H2 encoded alloantigens. The aim of this investigation was to test the possibly differential effects of sex-associated inflammatory responses evoked by these alloantigens on osteoneogenesis of the fetal bone allograft and the differentiation of associated cellular elements (i.e., bone marrow). From the results of our present study, it appears that the sex of the recipient and the extent of histoincompatibility at both (MHC) H2 and non-H2 genes of the fetal graft determine the character of the inflammatory processes evoked by the graft, and in turn, the developmental fate in terms of histogenetic ossification processes. In the case of the allograft, the greater the immunogenetic gap the more intense were both the inflammatory responses in the female recipients and the extent of osteoneogenesis, particularly of enchondral bone in the females.
AB - Fetal bone allografts were transplanted in male and female recipients differing in major histocompatibility (MHC) H2 and non-H2 encoded alloantigens. The aim of this investigation was to test the possibly differential effects of sex-associated inflammatory responses evoked by these alloantigens on osteoneogenesis of the fetal bone allograft and the differentiation of associated cellular elements (i.e., bone marrow). From the results of our present study, it appears that the sex of the recipient and the extent of histoincompatibility at both (MHC) H2 and non-H2 genes of the fetal graft determine the character of the inflammatory processes evoked by the graft, and in turn, the developmental fate in terms of histogenetic ossification processes. In the case of the allograft, the greater the immunogenetic gap the more intense were both the inflammatory responses in the female recipients and the extent of osteoneogenesis, particularly of enchondral bone in the females.
UR - http://www.scopus.com/inward/record.url?scp=85054260431&partnerID=8YFLogxK
U2 - 10.1201/9781351077194
DO - 10.1201/9781351077194
M3 - Chapter
AN - SCOPUS:85054260431
SN - 0849346258
SN - 9781315898094
SP - 85
EP - 102
BT - The Neuroendocrine Immune Network
PB - CRC Press
ER -