Differential uptake of myo-inositol in vivo into rat brain areas

Yardena Patishi; Beate Lubrich; Mathias Berger; Ora Kofman; Dietrich Van Calker; R. H. Belmaker

doi:10.1016/0924-977X(95)00061-S

Differential uptake of myo-inositol in vivo into rat brain areas

Yardena Patishi, Beate Lubrich, Mathias Berger, Ora Kofman, Dietrich Van Calker, R. H. Belmaker

Department of Psychology

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Oral inositol has been reported to have antidepressant and antipanic properties in humans. Inositol enters the brain poorly and high doses are required. Natural uptake processes and specific transporters are involved. We here report that intraperitoneally administered inositol is taken up differently by various brain areas and that brain areas have different baseline inositol levels. These effects could be important in understanding the differential effects of lithium-induced lowering of inositol and of behavioral effects of exogenous inositol.

Original language	English
Pages (from-to)	73-75
Number of pages	3
Journal	European Neuropsychopharmacology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/0924-977X(95)00061-S
State	Published - 1 Jan 1996

Keywords

Brain areas
Inositol
Uptake

ASJC Scopus subject areas

Pharmacology
Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0924-977X(95)00061-S

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title = "Differential uptake of myo-inositol in vivo into rat brain areas",

abstract = "Oral inositol has been reported to have antidepressant and antipanic properties in humans. Inositol enters the brain poorly and high doses are required. Natural uptake processes and specific transporters are involved. We here report that intraperitoneally administered inositol is taken up differently by various brain areas and that brain areas have different baseline inositol levels. These effects could be important in understanding the differential effects of lithium-induced lowering of inositol and of behavioral effects of exogenous inositol.",

keywords = "Brain areas, Inositol, Uptake",

author = "Yardena Patishi and Beate Lubrich and Mathias Berger and Ora Kofman and {Van Calker}, Dietrich and Belmaker, {R. H.}",

note = "Funding Information: This work was supported by a grant from the German-Israel Foundation, Grant No. 1-245-098.02/92. The authors wish to thank Dr. Richard S. Jope for stimulating comments on the manuscript.",

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doi = "10.1016/0924-977X(95)00061-S",

language = "English",

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T1 - Differential uptake of myo-inositol in vivo into rat brain areas

AU - Patishi, Yardena

AU - Lubrich, Beate

AU - Berger, Mathias

AU - Kofman, Ora

AU - Van Calker, Dietrich

AU - Belmaker, R. H.

N1 - Funding Information: This work was supported by a grant from the German-Israel Foundation, Grant No. 1-245-098.02/92. The authors wish to thank Dr. Richard S. Jope for stimulating comments on the manuscript.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Oral inositol has been reported to have antidepressant and antipanic properties in humans. Inositol enters the brain poorly and high doses are required. Natural uptake processes and specific transporters are involved. We here report that intraperitoneally administered inositol is taken up differently by various brain areas and that brain areas have different baseline inositol levels. These effects could be important in understanding the differential effects of lithium-induced lowering of inositol and of behavioral effects of exogenous inositol.

AB - Oral inositol has been reported to have antidepressant and antipanic properties in humans. Inositol enters the brain poorly and high doses are required. Natural uptake processes and specific transporters are involved. We here report that intraperitoneally administered inositol is taken up differently by various brain areas and that brain areas have different baseline inositol levels. These effects could be important in understanding the differential effects of lithium-induced lowering of inositol and of behavioral effects of exogenous inositol.

KW - Brain areas

KW - Inositol

KW - Uptake

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DO - 10.1016/0924-977X(95)00061-S

M3 - Article

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SN - 0924-977X

VL - 6

SP - 73

EP - 75

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JF - European Neuropsychopharmacology

IS - 1

ER -

Differential uptake of myo-inositol in vivo into rat brain areas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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