Of 100 epileptic patients treated with diphenylhydantoin (DPH), eight had clinical signs of DPH intoxication. Plasma DPH concentration in the latter varied from 18.3 μg/ml to 53 μg/ml, and the mean DPH concentration in CSF was 5.6 μg/ml. Clinical signs of intoxication included horizontal and vertical nystagmus, ataxia, drowsiness and choreo athetosis. No close parallelism was found between signs of DPH intoxication and plasma concentrations of DPH. However, horizontal and vertical nystagmus occurred in patients with very high levels of DPH (30-53 μg/mg).
|State||Published - 1 Jan 1975|
ASJC Scopus subject areas
- Medicine (all)