Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics

Keyphrases

• Indirect Mechanism 100%
• KLK4 100%
• Sunflower Trypsin Inhibitor 40%
• Human Health 20%
• In Cancer 20%
• Human Disease 20%
• Protease 20%
• Active Sites 20%
• Molecular Dynamics Simulation 20%
• Cancer Metastasis 20%
• Simulation Analysis 20%
• Rationally Designed 20%
• Serine Protease 20%
• Metal Binding 20%
• Cancer Development 20%
• Inhibition Mechanism 20%
• Mode of Inhibition 20%
• Computational Analysis 20%
• Kallikrein-related Peptidases 20%
• X-ray Crystal Structure 20%
• Inactivation Mechanism 20%
• Enzymology 20%
• Therapeutic Inhibitors 20%
• Dynamic Pathway 20%
• Exosite 20%

Biochemistry, Genetics and Molecular Biology

• Dynamics 100%
• KLK4 100%
• Helianthus annuus 40%
• Trypsin Inhibitor 40%
• X Ray 20%
• Serine Protease 20%
• Protease 20%
• Peptidase 20%
• Metal Binding 20%
• Active Site 20%
• Crystal Structure 20%
• Kallikrein 20%
• Enzymology 20%
• Exosite 20%