Direct Measurement of Vena Contracta Area by Real-Time 3-Dimensional Echocardiography for Assessing Severity of Mitral Regurgitation

Chaim Yosefy, Judy Hung, Sarah Chua, Mordehay Vaturi, Thanh Thao Ton-Nu, Mark D. Handschumacher, Robert A. Levine

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

We tested the hypothesis that the vena contracta (VC) cross-sectional area in patients with mitral regurgitation (MR) can be reproducibly measured by real-time 3-dimensional (3D) echocardiography and correlates well with the volumetric effective regurgitant orifice area (EROA). Earlier MR repair requires accurate noninvasive measures, but practically, the VC area is difficult to image in 2-dimensional views, which are often oblique to it. 3D echocardiography can provide an otherwise unobtainable true cross-sectional view. In 45 patients with mild or greater MR, 44% eccentric, 2-dimensional and 3D VC areas were measured and correlated with the EROA derived from the regurgitant stroke volume. Real-time 3D echocardiography of the VC area correlated and agreed well with the EROA for both central and eccentric jets (r2 = 0.86, SEE 0.02 cm2, difference 0.04 ± 0.06 cm2, p = NS). For eccentric jets, 2-dimensional echocardiography overestimated the VC width compared with 3D echocardiography (p = 0.024) and correlated more poorly with the EROA (r2 = 0.61 vs 0.85, p <0.001), causing clinical misclassification in 45% of patients with eccentric MR. The interobserver variability for the 3D VC area was 0.03 cm2 (7.5% of the mean, r = 0.95); the intraobserver variability was 0.01 cm2 (2.5% of the mean, r = 0.97). In conclusion, real-time 3D echocardiography accurately and reproducibly quantified the vena contracta cross-sectional area in patients with both central and eccentric MR. Rapid acquisition and intuitive analysis promote practical clinical application of this central, directly visualized, measure and its correlation with outcome.

Original languageEnglish
Pages (from-to)978-983
Number of pages6
JournalAmerican Journal of Cardiology
Volume104
Issue number7
DOIs
StatePublished - 1 Oct 2009
Externally publishedYes

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