Abstract
A small series of biaryl ether containing cyclic peptidic scaffolds was synthesized and cyclized by an SNAr reaction. The structure of one rigid scaffold was solved, by X-ray crystallography and also determined in solution by NMR spectroscopy. Molecular alignment of the peptidic scaffold in strained PH polymer gels in [DG]DMSO was applied to ex-tract residual dipolar couplings (RDCs). The RDC values were used to obtain a structure that was compared to the crystal structure. Good correlation was obtained, indicating that the RDC method represents a very precise structure determination method for small organic molecules in solution.
Original language | English |
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Pages (from-to) | 4501-4507 |
Number of pages | 7 |
Journal | European Journal of Organic Chemistry |
Issue number | 23 |
DOIs | |
State | Published - 1 Aug 2010 |
Externally published | Yes |
Keywords
- Amino acids
- Nmr spectroscopy
- Peptides
- Structure elucidation
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry