Direct thrombin inhibitors

Rajeev Garg, Neal Kleiman, Eli Lev

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Role of thrombin in arterial thrombosis Thrombin (factor IIa) is a serine protease that is activated at the final step of the blood coagulation cascade and converts fibrinogen to fibrin. Thrombin has multiple roles - it is the most potent known platelet agonist, it is primarily responsible for thrombus propagation through the soluble clotting cascade, and it is also responsible for both positive and negative feedback within the coagulation cascade.

Original languageEnglish
Title of host publicationClinical Guide to the Use of Antithrombotic Drugs in Coronary Artery Disease
PublisherCRC Press
Number of pages9
ISBN (Electronic)9780203091494
ISBN (Print)9781841846392
StatePublished - 1 Jan 2008
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics (all)


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